Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.

Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells.

CD4(+) T cells are thought to be critical in the maintenance of virus-specific CD8(+) cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in HIV-1-specific CTL as the CD4(+) T-cell count decreases has been reported. Using HLA-peptide tetram...

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Bibliographic Details
Main Authors: Spiegel, H, Ogg, G, DeFalcon, E, Sheehy, M, Monard, S, Haslett, P, Gillespie, G, Donahoe, S, Pollack, H, Borkowsky, W, Mcmichael, A, Nixon, D
Format: Journal article
Language:English
Published: 2000

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