MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT cells are activated by a broad range of bacteria through detection of riboflavin metabolites bound by MR1, but the...

Bibliográfalaš dieđut
Váldodahkkit:	Kurioka, A, Ussher, J, Cosgrove, C, Clough, C, Fergusson, JR, Smith, K, Kang, Y, Walker, L, Hansen, T, Willberg, C, Klenerman, P
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Nature Publishing Group 2015

Geahča maid

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MAIT cells are enriched in portal tracts and respond to biliary epithelial cells presenting bacterial ligands during liver inflammation
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MAIT cells are activated during human viral infections
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Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism
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MR1-dependent activation of intrahepatic MAIT cells by bacterially exposed biliary epithelial cells and liver B cells
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Tobacco companies legally licensed to kill
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MAIT cells protect against sterile lung injury
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Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality
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