Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.

Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT). The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, re...

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Main Authors: Froese, D, Kochan, G, Muniz, JR, Wu, X, Gileadi, C, Ugochukwu, E, Krysztofinska, E, Gravel, R, Oppermann, U, Yue, W
Format: Journal article
Jezik:English
Izdano: 2010