Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.

The hph-1 ENU-mutant mouse provides a model of tetrahydrobiopterin deficiency for studying hyperphenylalaninaemia, dopa-response dystonia, and vascular dysfunction. We have successively localized the hph-1 mutation to a congenic interval of 1.6-2.8 Mb, containing the GCH gene encoding GTP cyclohydro...

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Bibliographic Details
Main Authors:	Khoo, J, Nicoli, T, Alp, N, Fullerton, J, Flint, J, Channon, K
Format:	Journal article
Language:	English
Published:	2004

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