2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation.
A fixed microelectrode device for cell stimulation has been designed and fabricated using micro-electro-mechanical systems (MEMS) technology. Dielectrophoretic forces obtained from non-uniform electric fields were used for manipulating and positioning osteoblasts. The experiments show that the osteo...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797099651180003328 |
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| author | Zou, H Mellon, S Syms, R Tanner, K |
| author_facet | Zou, H Mellon, S Syms, R Tanner, K |
| author_sort | Zou, H |
| collection | OXFORD |
| description | A fixed microelectrode device for cell stimulation has been designed and fabricated using micro-electro-mechanical systems (MEMS) technology. Dielectrophoretic forces obtained from non-uniform electric fields were used for manipulating and positioning osteoblasts. The experiments show that the osteoblasts experience positive dielectrophoresis (p-DEP) when suspended in iso-osmotic culture medium and exposed to AC fields at 5 MHz frequency. Negative dielectrophoresis (n-DEP) is obtained at 0.1 MHz. The viability of osteoblasts under dielectrophoresis has been investigated. The viability values for cells exposed to DEP are nearly three times higher than the control values, indicating that dielectrophoresis may have an anabolic effect on osteoblasts. |
| first_indexed | 2024-03-07T05:26:44Z |
| format | Journal article |
| id | oxford-uuid:e0d22756-8787-482d-8c14-8ddc2cc384b8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:26:44Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:e0d22756-8787-482d-8c14-8ddc2cc384b82022-03-27T09:50:03Z2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e0d22756-8787-482d-8c14-8ddc2cc384b8EnglishSymplectic Elements at Oxford2006Zou, HMellon, SSyms, RTanner, KA fixed microelectrode device for cell stimulation has been designed and fabricated using micro-electro-mechanical systems (MEMS) technology. Dielectrophoretic forces obtained from non-uniform electric fields were used for manipulating and positioning osteoblasts. The experiments show that the osteoblasts experience positive dielectrophoresis (p-DEP) when suspended in iso-osmotic culture medium and exposed to AC fields at 5 MHz frequency. Negative dielectrophoresis (n-DEP) is obtained at 0.1 MHz. The viability of osteoblasts under dielectrophoresis has been investigated. The viability values for cells exposed to DEP are nearly three times higher than the control values, indicating that dielectrophoresis may have an anabolic effect on osteoblasts. |
| spellingShingle | Zou, H Mellon, S Syms, R Tanner, K 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title | 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title_full | 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title_fullStr | 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title_full_unstemmed | 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title_short | 2-Dimensional MEMS dielectrophoresis device for osteoblast cell stimulation. |
| title_sort | 2 dimensional mems dielectrophoresis device for osteoblast cell stimulation |
| work_keys_str_mv | AT zouh 2dimensionalmemsdielectrophoresisdeviceforosteoblastcellstimulation AT mellons 2dimensionalmemsdielectrophoresisdeviceforosteoblastcellstimulation AT symsr 2dimensionalmemsdielectrophoresisdeviceforosteoblastcellstimulation AT tannerk 2dimensionalmemsdielectrophoresisdeviceforosteoblastcellstimulation |