LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncont...

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প্রধান লেখক: Hacein-Bey-Abina, S, Von Kalle, C, Schmidt, M, McCormack, M, Wulffraat, N, Leboulch, P, Lim, A, Osborne, C, Pawliuk, R, Morillon, E, Sorensen, R, Forster, A, Fraser, P, Cohen, J, de Saint Basile, G, Alexander, I, Wintergerst, U, Frebourg, T, Aurias, A, Stoppa-Lyonnet, D, Romana, S, Radford-Weiss, I, Gross, F, Valensi, F, Delabesse, E
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2003

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