LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncont...

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Hlavní autoři:	Hacein-Bey-Abina, S, Von Kalle, C, Schmidt, M, McCormack, M, Wulffraat, N, Leboulch, P, Lim, A, Osborne, C, Pawliuk, R, Morillon, E, Sorensen, R, Forster, A, Fraser, P, Cohen, J, de Saint Basile, G, Alexander, I, Wintergerst, U, Frebourg, T, Aurias, A, Stoppa-Lyonnet, D, Romana, S, Radford-Weiss, I, Gross, F, Valensi, F, Delabesse, E
Médium:	Journal article
Jazyk:	English
Vydáno:	2003

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

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