LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncont...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Hacein-Bey-Abina, S, Von Kalle, C, Schmidt, M, McCormack, M, Wulffraat, N, Leboulch, P, Lim, A, Osborne, C, Pawliuk, R, Morillon, E, Sorensen, R, Forster, A, Fraser, P, Cohen, J, de Saint Basile, G, Alexander, I, Wintergerst, U, Frebourg, T, Aurias, A, Stoppa-Lyonnet, D, Romana, S, Radford-Weiss, I, Gross, F, Valensi, F, Delabesse, E
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2003