LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncont...

全面介紹

書目詳細資料
Main Authors: Hacein-Bey-Abina, S, Von Kalle, C, Schmidt, M, McCormack, M, Wulffraat, N, Leboulch, P, Lim, A, Osborne, C, Pawliuk, R, Morillon, E, Sorensen, R, Forster, A, Fraser, P, Cohen, J, de Saint Basile, G, Alexander, I, Wintergerst, U, Frebourg, T, Aurias, A, Stoppa-Lyonnet, D, Romana, S, Radford-Weiss, I, Gross, F, Valensi, F, Delabesse, E
格式: Journal article
語言:English
出版: 2003

相似書籍