The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.

The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.

OBJECTIVES: Endothelin-1 (ET-1) is a key regulator of arterial blood pressure in humans, and homocysteinemia is associated with increased oxidative stress. It is still unclear whether homocysteine-induced oxidative stress is implicated in the regulation of ET-1 expression. We examined the impact of...

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Bibliographic Details
Main Authors:	Tousoulis, D, Bouras, G, Antoniades, C, Marinou, K, Miliou, A, Papageorgiou, N, Chatzis, G, Tentolouris, C, Tsioufis, C, Stefanadis, C
Format:	Journal article
Language:	English
Published:	2010

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