Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T.
OBJECTIVES: To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN: Names were randomly selected from immunisation records. Families were visited on f...
| Autori principali: | , , , , , |
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| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
1997
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| _version_ | 1826301100641222656 |
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| author | Heath, P Bowen-Morris, J Griffiths, D Griffiths, H Crook, D Moxon, E |
| author_facet | Heath, P Bowen-Morris, J Griffiths, D Griffiths, H Crook, D Moxon, E |
| author_sort | Heath, P |
| collection | OXFORD |
| description | OBJECTIVES: To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN: Names were randomly selected from immunisation records. Families were visited on five occasions over a period of 12 months and throat swabs were taken from all family members present, with blood obtained from children at the first and last visits. RESULTS: One hundred and fifty three children at a median age of 3.6 years had a geometric mean titre (GMT) of 1.06 micrograms/ml (95% CI 0.80 to 1.38). Eight per cent had an undetectable antibody concentration, received a booster dose of plain PRP vaccine, and responded with concentrations > 2 micrograms/ml. GMT at 4.5 years of age was 0.89 microgram/ml (0.69 to 1.16). Twelve children who had been exposed to H influenzae had a GMT of 4.7 v 0.8 micrograms/ml for those without exposure. CONCLUSIONS: Accelerated immunisation against H influenzae without a second year booster results in persistence of satisfactory serum concentrations of antibody to 4.5 years of age. In those with undetectable antibody, immunological memory may still be present. |
| first_indexed | 2024-03-07T05:27:16Z |
| format | Journal article |
| id | oxford-uuid:e0feda0b-9c15-4fc9-abd0-af33cb9c388c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:27:16Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:e0feda0b-9c15-4fc9-abd0-af33cb9c388c2022-03-27T09:51:18ZAntibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e0feda0b-9c15-4fc9-abd0-af33cb9c388cEnglishSymplectic Elements at Oxford1997Heath, PBowen-Morris, JGriffiths, DGriffiths, HCrook, DMoxon, EOBJECTIVES: To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN: Names were randomly selected from immunisation records. Families were visited on five occasions over a period of 12 months and throat swabs were taken from all family members present, with blood obtained from children at the first and last visits. RESULTS: One hundred and fifty three children at a median age of 3.6 years had a geometric mean titre (GMT) of 1.06 micrograms/ml (95% CI 0.80 to 1.38). Eight per cent had an undetectable antibody concentration, received a booster dose of plain PRP vaccine, and responded with concentrations > 2 micrograms/ml. GMT at 4.5 years of age was 0.89 microgram/ml (0.69 to 1.16). Twelve children who had been exposed to H influenzae had a GMT of 4.7 v 0.8 micrograms/ml for those without exposure. CONCLUSIONS: Accelerated immunisation against H influenzae without a second year booster results in persistence of satisfactory serum concentrations of antibody to 4.5 years of age. In those with undetectable antibody, immunological memory may still be present. |
| spellingShingle | Heath, P Bowen-Morris, J Griffiths, D Griffiths, H Crook, D Moxon, E Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title | Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title_full | Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title_fullStr | Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title_full_unstemmed | Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title_short | Antibody persistence and Haemophilus influenzae type b carriage after infant immunisation with PRP-T. |
| title_sort | antibody persistence and haemophilus influenzae type b carriage after infant immunisation with prp t |
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