Antibodies to tubulin in patients with parasitic infections.
Sera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin anti...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1797099712849903616 |
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| author | Howard, M Gull, K Miles, M |
| author_facet | Howard, M Gull, K Miles, M |
| author_sort | Howard, M |
| collection | OXFORD |
| description | Sera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin antibody were significantly elevated in 67% of patients with visceral leishmaniasis, in 60% of patients with cutaneous leishmaniasis, in 89% of patients with onchocerciasis, in 100% of patients with schistosomiasis, and in 94% of patients with leprosy. Little or no increase in anti-tubulin antibody levels was seen in sera from patients with malaria (Plasmodium vivax) or tuberculosis. |
| first_indexed | 2024-03-07T05:27:30Z |
| format | Journal article |
| id | oxford-uuid:e1141892-366b-4eb1-ac22-ab1c1c665687 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:27:30Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:e1141892-366b-4eb1-ac22-ab1c1c6656872022-03-27T09:51:45ZAntibodies to tubulin in patients with parasitic infections.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1141892-366b-4eb1-ac22-ab1c1c665687EnglishSymplectic Elements at Oxford1987Howard, MGull, KMiles, MSera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin antibody were significantly elevated in 67% of patients with visceral leishmaniasis, in 60% of patients with cutaneous leishmaniasis, in 89% of patients with onchocerciasis, in 100% of patients with schistosomiasis, and in 94% of patients with leprosy. Little or no increase in anti-tubulin antibody levels was seen in sera from patients with malaria (Plasmodium vivax) or tuberculosis. |
| spellingShingle | Howard, M Gull, K Miles, M Antibodies to tubulin in patients with parasitic infections. |
| title | Antibodies to tubulin in patients with parasitic infections. |
| title_full | Antibodies to tubulin in patients with parasitic infections. |
| title_fullStr | Antibodies to tubulin in patients with parasitic infections. |
| title_full_unstemmed | Antibodies to tubulin in patients with parasitic infections. |
| title_short | Antibodies to tubulin in patients with parasitic infections. |
| title_sort | antibodies to tubulin in patients with parasitic infections |
| work_keys_str_mv | AT howardm antibodiestotubulininpatientswithparasiticinfections AT gullk antibodiestotubulininpatientswithparasiticinfections AT milesm antibodiestotubulininpatientswithparasiticinfections |