Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene.
The duplicated human embryonic alpha-like globin genes encode a 5' functional zeta (xi 2) gene and a highly homologous pseudogene (psi xi 1). We have identified chromosomes with a xi 2-xi 1 rather than a xi 2-psi xi 1 arrangement by genomic mapping and oligonucleotide analysis. The DNA sequence...
| Автори: | , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
1985
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| _version_ | 1826301116244033536 |
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| author | Hill, A Nicholls, R Thein, S Higgs, D |
| author_facet | Hill, A Nicholls, R Thein, S Higgs, D |
| author_sort | Hill, A |
| collection | OXFORD |
| description | The duplicated human embryonic alpha-like globin genes encode a 5' functional zeta (xi 2) gene and a highly homologous pseudogene (psi xi 1). We have identified chromosomes with a xi 2-xi 1 rather than a xi 2-psi xi 1 arrangement by genomic mapping and oligonucleotide analysis. The DNA sequence of a cloned downstream xi-like gene provides direct evidence for the conversion of a psi xi 1----xi 1 gene, by a xi 2 gene. We present data suggesting that this gene conversion, which removed the only identifiable inactivating mutation in the psi xi 1 gene, was an interchromosomal event. The xi 2-xi 1 arrangement is common in all eight populations studied representing a previously undescribed type of polymorphism between individuals. Stable mRNA transcripts from the converted gene are absent at 16-20 weeks of gestation when transcripts from the xi 2 gene are readily detectable. |
| first_indexed | 2024-03-07T05:27:30Z |
| format | Journal article |
| id | oxford-uuid:e114240a-e67d-437d-a55d-0fa188e98dc6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:27:30Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:e114240a-e67d-437d-a55d-0fa188e98dc62022-03-27T09:51:46ZRecombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e114240a-e67d-437d-a55d-0fa188e98dc6EnglishSymplectic Elements at Oxford1985Hill, ANicholls, RThein, SHiggs, DThe duplicated human embryonic alpha-like globin genes encode a 5' functional zeta (xi 2) gene and a highly homologous pseudogene (psi xi 1). We have identified chromosomes with a xi 2-xi 1 rather than a xi 2-psi xi 1 arrangement by genomic mapping and oligonucleotide analysis. The DNA sequence of a cloned downstream xi-like gene provides direct evidence for the conversion of a psi xi 1----xi 1 gene, by a xi 2 gene. We present data suggesting that this gene conversion, which removed the only identifiable inactivating mutation in the psi xi 1 gene, was an interchromosomal event. The xi 2-xi 1 arrangement is common in all eight populations studied representing a previously undescribed type of polymorphism between individuals. Stable mRNA transcripts from the converted gene are absent at 16-20 weeks of gestation when transcripts from the xi 2 gene are readily detectable. |
| spellingShingle | Hill, A Nicholls, R Thein, S Higgs, D Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title | Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title_full | Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title_fullStr | Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title_full_unstemmed | Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title_short | Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. |
| title_sort | recombination within the human embryonic xi globin locus a common xi xi chromosome produced by gene conversion of the psi xi gene |
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