HIV-1 transmission patterns within and between risk groups in Coastal Kenya
HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature
2020
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| _version_ | 1797099761856151552 |
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| author | Nduva, GM Hassan, AS Nazziwa, J Graham, SM Esbjörnsson, J Sanders, EJ |
| author_facet | Nduva, GM Hassan, AS Nazziwa, J Graham, SM Esbjörnsson, J Sanders, EJ |
| author_sort | Nduva, GM |
| collection | OXFORD |
| description | HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005-2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The remaining clusters were mixed between HET/MSM (7%), HET/FSW (5%), and MSM/FSW (3%) sequences. One large IDU-exclusive cluster was found, indicating an independent sub-epidemic among this group. Phylodynamic analysis of this cluster revealed a steady increase in HIV-1 infections among IDU since the estimated origin of the cluster in 1987. Our results suggest mixing between high-risk groups and heterosexual populations and could be relevant for the development of targeted HIV-1 prevention programmes in coastal Kenya. |
| first_indexed | 2024-03-07T05:28:12Z |
| format | Journal article |
| id | oxford-uuid:e147ab5a-8945-4786-859d-a2db931840f8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:12Z |
| publishDate | 2020 |
| publisher | Nature |
| record_format | dspace |
| spelling | oxford-uuid:e147ab5a-8945-4786-859d-a2db931840f82022-03-27T09:53:24ZHIV-1 transmission patterns within and between risk groups in Coastal KenyaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e147ab5a-8945-4786-859d-a2db931840f8EnglishSymplectic ElementsNature2020Nduva, GMHassan, ASNazziwa, JGraham, SMEsbjörnsson, JSanders, EJHIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005-2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The remaining clusters were mixed between HET/MSM (7%), HET/FSW (5%), and MSM/FSW (3%) sequences. One large IDU-exclusive cluster was found, indicating an independent sub-epidemic among this group. Phylodynamic analysis of this cluster revealed a steady increase in HIV-1 infections among IDU since the estimated origin of the cluster in 1987. Our results suggest mixing between high-risk groups and heterosexual populations and could be relevant for the development of targeted HIV-1 prevention programmes in coastal Kenya. |
| spellingShingle | Nduva, GM Hassan, AS Nazziwa, J Graham, SM Esbjörnsson, J Sanders, EJ HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title | HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title_full | HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title_fullStr | HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title_full_unstemmed | HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title_short | HIV-1 transmission patterns within and between risk groups in Coastal Kenya |
| title_sort | hiv 1 transmission patterns within and between risk groups in coastal kenya |
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