Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism
<p><strong>Aims</strong> Whether diabetes increases venous thromboembolism (VTE) is unclear. Any greater risk may relate to insulin resistance, but many studies did not differentiate between type 1 diabetes and type 2 diabetes for VTE risk.</p> <p><strong>Methods...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2020
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| _version_ | 1797099764275216384 |
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| author | Hinton, W Nemeth, B de Lusignan, S Field, B Feher, MD Munro, N Roberts, LN Arya, R Whyte, MB |
| author_facet | Hinton, W Nemeth, B de Lusignan, S Field, B Feher, MD Munro, N Roberts, LN Arya, R Whyte, MB |
| author_sort | Hinton, W |
| collection | OXFORD |
| description | <p><strong>Aims</strong>
Whether diabetes increases venous thromboembolism (VTE) is unclear. Any greater risk may relate to insulin resistance, but many studies did not differentiate between type 1 diabetes and type 2 diabetes for VTE risk.</p>
<p><strong>Methods</strong>
Retrospective cohort study of the Royal College of General Practitioners Research and Surveillance Centre, comprising over 530 primary care practices. We determined whether type 1 diabetes and/or type 2 diabetes are independent risk factors for VTE. The index date was 1 January 2009, individuals were followed to 31 December 2018, or censoring. Cox proportional hazard regression analysis was used to investigate the risk of VTE in people with type 1 diabetes and type 2 diabetes relative to no diabetes. The primary outcome was occurrence of VTE. The model was adjusted for potential confounders for VTE.</p>
<p><strong>Results</strong>
There were 7086 people with type 1 diabetes and 95,566 with type 2 diabetes, diagnosed before 1 January 2009. The non-diabetes group consisted of 1,407,699 people. In the unadjusted analysis, there was no increased risk of VTE with type 1 diabetes (HR 1.00, 95% CI 0.76–1.33) but there was for type 2 diabetes (HR 2.70, 95% CI 2.57–2.84). In the fully adjusted model, VTE risk was increased in type 1 diabetes (HR 1.46, 95% CI 1.11–1.92), but not with type 2 diabetes (HR 1.06, 95% CI 0.98–1.14).</p>
<p><strong>Conclusions</strong>
Type 1 diabetes was associated with a greater risk for VTE while type 2 diabetes was not. Further work is needed to determine the reason(s) for this.</p> |
| first_indexed | 2024-03-07T05:28:14Z |
| format | Journal article |
| id | oxford-uuid:e14aad72-4ac1-4606-8db5-8d345cf00ebe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:14Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:e14aad72-4ac1-4606-8db5-8d345cf00ebe2022-03-27T09:53:33ZEffect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolismJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e14aad72-4ac1-4606-8db5-8d345cf00ebeEnglishSymplectic ElementsWiley2020Hinton, WNemeth, Bde Lusignan, SField, BFeher, MDMunro, NRoberts, LNArya, RWhyte, MB<p><strong>Aims</strong> Whether diabetes increases venous thromboembolism (VTE) is unclear. Any greater risk may relate to insulin resistance, but many studies did not differentiate between type 1 diabetes and type 2 diabetes for VTE risk.</p> <p><strong>Methods</strong> Retrospective cohort study of the Royal College of General Practitioners Research and Surveillance Centre, comprising over 530 primary care practices. We determined whether type 1 diabetes and/or type 2 diabetes are independent risk factors for VTE. The index date was 1 January 2009, individuals were followed to 31 December 2018, or censoring. Cox proportional hazard regression analysis was used to investigate the risk of VTE in people with type 1 diabetes and type 2 diabetes relative to no diabetes. The primary outcome was occurrence of VTE. The model was adjusted for potential confounders for VTE.</p> <p><strong>Results</strong> There were 7086 people with type 1 diabetes and 95,566 with type 2 diabetes, diagnosed before 1 January 2009. The non-diabetes group consisted of 1,407,699 people. In the unadjusted analysis, there was no increased risk of VTE with type 1 diabetes (HR 1.00, 95% CI 0.76–1.33) but there was for type 2 diabetes (HR 2.70, 95% CI 2.57–2.84). In the fully adjusted model, VTE risk was increased in type 1 diabetes (HR 1.46, 95% CI 1.11–1.92), but not with type 2 diabetes (HR 1.06, 95% CI 0.98–1.14).</p> <p><strong>Conclusions</strong> Type 1 diabetes was associated with a greater risk for VTE while type 2 diabetes was not. Further work is needed to determine the reason(s) for this.</p> |
| spellingShingle | Hinton, W Nemeth, B de Lusignan, S Field, B Feher, MD Munro, N Roberts, LN Arya, R Whyte, MB Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title | Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title_full | Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title_fullStr | Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title_full_unstemmed | Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title_short | Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
| title_sort | effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism |
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