Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles
<p>Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it fo...
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| Format: | Journal article |
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Multidisciplinary Digital Publishing Institute
2017
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| _version_ | 1826301166919614464 |
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| author | Ford, JE Stansfeld, PJ Vakonakis, I |
| author_facet | Ford, JE Stansfeld, PJ Vakonakis, I |
| author_sort | Ford, JE |
| collection | OXFORD |
| description | <p>Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it forms the central core of the organelle, which is then surrounded by microtubules. SAS-6 self-assembles into an oligomer with elongated spokes that emanate towards the outer microtubule wall; in this manner, the symmetry of the SAS-6 oligomer influences centriole architecture and symmetry. Here, we summarise the form and symmetry of SAS-6 oligomers inferred from crystal structures and directly observed in vitro. We discuss how the strict 9-fold symmetry of centrioles may emerge, and how different forms of SAS-6 oligomers may be accommodated in the organelle architecture.</p> |
| first_indexed | 2024-03-07T05:28:16Z |
| format | Journal article |
| id | oxford-uuid:e14edc0a-d09c-4008-9e65-6086859a9f47 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:28:16Z |
| publishDate | 2017 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | oxford-uuid:e14edc0a-d09c-4008-9e65-6086859a9f472022-03-27T09:53:34ZCoupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organellesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e14edc0a-d09c-4008-9e65-6086859a9f47Symplectic Elements at OxfordMultidisciplinary Digital Publishing Institute2017Ford, JEStansfeld, PJVakonakis, I<p>Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it forms the central core of the organelle, which is then surrounded by microtubules. SAS-6 self-assembles into an oligomer with elongated spokes that emanate towards the outer microtubule wall; in this manner, the symmetry of the SAS-6 oligomer influences centriole architecture and symmetry. Here, we summarise the form and symmetry of SAS-6 oligomers inferred from crystal structures and directly observed in vitro. We discuss how the strict 9-fold symmetry of centrioles may emerge, and how different forms of SAS-6 oligomers may be accommodated in the organelle architecture.</p> |
| spellingShingle | Ford, JE Stansfeld, PJ Vakonakis, I Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title | Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title_full | Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title_fullStr | Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title_full_unstemmed | Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title_short | Coupling form and function: how the oligomerisation symmetry of the SAS-6 protein contributes to the architecture of centriole organelles |
| title_sort | coupling form and function how the oligomerisation symmetry of the sas 6 protein contributes to the architecture of centriole organelles |
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