The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction.
Polymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absenc...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1975
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| _version_ | 1797099769332498432 |
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| author | Waldmann, H Munro, A |
| author_facet | Waldmann, H Munro, A |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | Polymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absence of thymus-derived cells (T cells). However, in the case of responses to soluble thymus-dependent conjugates, carrier-specific T cells would appear to be necessary for adjuvanticity to be expressed. On the basis of these observations an hypothesis for the mechanism of B-cell induction and tolerance is proposed. |
| first_indexed | 2024-03-07T05:28:19Z |
| format | Journal article |
| id | oxford-uuid:e152180e-96c8-4d5b-87c4-fe0b4af9071a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:19Z |
| publishDate | 1975 |
| record_format | dspace |
| spelling | oxford-uuid:e152180e-96c8-4d5b-87c4-fe0b4af9071a2022-03-27T09:53:37ZThe inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e152180e-96c8-4d5b-87c4-fe0b4af9071aEnglishSymplectic Elements at Oxford1975Waldmann, HMunro, APolymerized flagellin and E. coli lipopolysaccharide both express adjuvanticity in vivo and in vitro for responses to hapten conjugated to sheep erythrocytes, and hapten conjugated to soluble thymus-dependent antigens. In the case of erythrocyte-bound hapten, adjuvanticity is expressed in the absence of thymus-derived cells (T cells). However, in the case of responses to soluble thymus-dependent conjugates, carrier-specific T cells would appear to be necessary for adjuvanticity to be expressed. On the basis of these observations an hypothesis for the mechanism of B-cell induction and tolerance is proposed. |
| spellingShingle | Waldmann, H Munro, A The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title | The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title_full | The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title_fullStr | The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title_full_unstemmed | The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title_short | The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction. |
| title_sort | inter relationship of antigenic structure thymus independence and adjuvanticity iv a general model for b cell induction |
| work_keys_str_mv | AT waldmannh theinterrelationshipofantigenicstructurethymusindependenceandadjuvanticityivageneralmodelforbcellinduction AT munroa theinterrelationshipofantigenicstructurethymusindependenceandadjuvanticityivageneralmodelforbcellinduction AT waldmannh interrelationshipofantigenicstructurethymusindependenceandadjuvanticityivageneralmodelforbcellinduction AT munroa interrelationshipofantigenicstructurethymusindependenceandadjuvanticityivageneralmodelforbcellinduction |