Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.

Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis.

Mouse models of the GM2 gangliosidoses [Tay-Sachs, late onset Tay-Sachs (LOTS), Sandhoff] and GM1 gangliosidosis have been studied to determine whether there is a common neuro-inflammatory component to these disorders. During the disease course, we have: (i) examined the expression of a number of in...

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Detalhes bibliográficos
Main Authors: Jeyakumar, M, Thomas, R, Elliot-Smith, E, Smith, D, van der Spoel, A, d'Azzo, A, Perry, V, Butters, T, Dwek, R, Platt, F
Formato: Journal article
Idioma:English
Publicado em: 2003

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