P450–Mediated azepane natural product synthesis
<p>Chapter 1 introduces methods and applications for C–H activation, cytochrome P450 enzymes and their uses in synthesis, and the relevant families of compounds in which the present work takes place.</p> <p>Chapter 2 describes the strategy and the attempts of building the natural p...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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2023
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| _version_ | 1797111856194650112 |
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| author | Rouffeteau, VAA |
| author2 | Robertson, J |
| author_facet | Robertson, J Rouffeteau, VAA |
| author_sort | Rouffeteau, VAA |
| collection | OXFORD |
| description | <p>Chapter 1 introduces methods and applications for C–H activation, cytochrome P450 enzymes and their uses in synthesis, and the relevant families of compounds in which the present work takes place.</p>
<p>Chapter 2 describes the strategy and the attempts of building the natural product balanol and analogues via C–H amination from enzymatically made substrate, along with new bicyclic lactones synthesised via C–H activation.</p>
<p>Chapter 3 presents progress in the synthesis of the carbon skeleton of the natural product cephalotaxine via an intramolecular Schmidt reaction, along with a significantly improved literature method for assembling the cephalotaxine core.</p>
<p>Chapter 4 explores the P450-catalysed oxidations of the previously made cephalotaxine core structure, to access new analogues of this natural product and to draw a P450-reactivity profile of this molecule.</p> |
| first_indexed | 2024-03-07T08:14:49Z |
| format | Thesis |
| id | oxford-uuid:e16844bd-7739-48d4-91a2-e6413a8973ae |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:14:49Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oxford-uuid:e16844bd-7739-48d4-91a2-e6413a8973ae2023-12-18T11:14:38ZP450–Mediated azepane natural product synthesisThesishttp://purl.org/coar/resource_type/c_bdccuuid:e16844bd-7739-48d4-91a2-e6413a8973aeChemistry, OrganicEnglishHyrax Deposit2023Rouffeteau, VAARobertson, J<p>Chapter 1 introduces methods and applications for C–H activation, cytochrome P450 enzymes and their uses in synthesis, and the relevant families of compounds in which the present work takes place.</p> <p>Chapter 2 describes the strategy and the attempts of building the natural product balanol and analogues via C–H amination from enzymatically made substrate, along with new bicyclic lactones synthesised via C–H activation.</p> <p>Chapter 3 presents progress in the synthesis of the carbon skeleton of the natural product cephalotaxine via an intramolecular Schmidt reaction, along with a significantly improved literature method for assembling the cephalotaxine core.</p> <p>Chapter 4 explores the P450-catalysed oxidations of the previously made cephalotaxine core structure, to access new analogues of this natural product and to draw a P450-reactivity profile of this molecule.</p> |
| spellingShingle | Chemistry, Organic Rouffeteau, VAA P450–Mediated azepane natural product synthesis |
| title | P450–Mediated azepane natural product synthesis |
| title_full | P450–Mediated azepane natural product synthesis |
| title_fullStr | P450–Mediated azepane natural product synthesis |
| title_full_unstemmed | P450–Mediated azepane natural product synthesis |
| title_short | P450–Mediated azepane natural product synthesis |
| title_sort | p450 mediated azepane natural product synthesis |
| topic | Chemistry, Organic |
| work_keys_str_mv | AT rouffeteauvaa p450mediatedazepanenaturalproductsynthesis |