Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India
Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We char...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
National Institute of Infectious Diseases
2023
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| _version_ | 1824458940266577920 |
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| author | Kaza, P Xavier, BB Mahindroo, J Singh, N Baker, S Nguyen, TNT Mavuduru, RS Mohan, B Taneja, N |
| author_facet | Kaza, P Xavier, BB Mahindroo, J Singh, N Baker, S Nguyen, TNT Mavuduru, RS Mohan, B Taneja, N |
| author_sort | Kaza, P |
| collection | OXFORD |
| description | Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We characterized the genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated tract infection at an Indian healthcare facility. The 18 organisms comprised the following sequence types (STs): ST14 (n = 9), ST147 (n = 5), ST231 (n = 2), ST2096 (n = 1), and ST25 (n = 1). Many patients in each ward were infected with the same ST, suggesting a common source of infection. Some patients had recurrent infections with multiple STs circulating in the ward, providing evidence of hospital transmission. β-lactamase genes (blaCTX-M-1, blaSHV, and blaampH) were present in all isolates. blaNDM-1 was present in 15 isolates, blaOXA-1 in 16 isolates, blaTEM-1D in 13 isolates, and blaOXA-48 in 3 isolates. Disruption of mgrB by various insertion sequences was responsible for colistin resistance in 6 isolates. The most common K-type among isolates was K2 (n = 10). One XDR convergent hvKp ST2096 mutation (iuc+ybt+blaOXA-1+blaOXA-48) was associated with prolonged hospitalization. Convergent XDR-hvKp has outbreak potential, warranting effective antimicrobial stewardship and infection control.
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| first_indexed | 2025-02-19T04:33:52Z |
| format | Journal article |
| id | oxford-uuid:e16a2c82-1ec1-4b8b-ad20-6173cf5cc641 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:33:52Z |
| publishDate | 2023 |
| publisher | National Institute of Infectious Diseases |
| record_format | dspace |
| spelling | oxford-uuid:e16a2c82-1ec1-4b8b-ad20-6173cf5cc6412025-01-15T10:55:47ZExtensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern IndiaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e16a2c82-1ec1-4b8b-ad20-6173cf5cc641EnglishSymplectic ElementsNational Institute of Infectious Diseases 2023Kaza, PXavier, BBMahindroo, JSingh, NBaker, SNguyen, TNTMavuduru, RSMohan, BTaneja, NKlebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. Understanding the genetic epidemiology of XDR-Kp can help determine its potential to be hypervirulent (hv) through the presence of siderophores. We characterized the genomes of 18 colistin-resistant XDR-Kp isolated from 14 patients with complicated tract infection at an Indian healthcare facility. The 18 organisms comprised the following sequence types (STs): ST14 (n = 9), ST147 (n = 5), ST231 (n = 2), ST2096 (n = 1), and ST25 (n = 1). Many patients in each ward were infected with the same ST, suggesting a common source of infection. Some patients had recurrent infections with multiple STs circulating in the ward, providing evidence of hospital transmission. β-lactamase genes (blaCTX-M-1, blaSHV, and blaampH) were present in all isolates. blaNDM-1 was present in 15 isolates, blaOXA-1 in 16 isolates, blaTEM-1D in 13 isolates, and blaOXA-48 in 3 isolates. Disruption of mgrB by various insertion sequences was responsible for colistin resistance in 6 isolates. The most common K-type among isolates was K2 (n = 10). One XDR convergent hvKp ST2096 mutation (iuc+ybt+blaOXA-1+blaOXA-48) was associated with prolonged hospitalization. Convergent XDR-hvKp has outbreak potential, warranting effective antimicrobial stewardship and infection control. |
| spellingShingle | Kaza, P Xavier, BB Mahindroo, J Singh, N Baker, S Nguyen, TNT Mavuduru, RS Mohan, B Taneja, N Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title | Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title_full | Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title_fullStr | Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title_full_unstemmed | Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title_short | Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India |
| title_sort | extensively drug resistant klebsiella pneumoniae associated with complicated urinary tract infection in northern india |
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