Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.

Arylamine N-acetyltransferase (NAT) acetylates the front-line anti-tuberculosis drug isoniazid (INH) and has been identified in Mycobacterium tuberculosis. A naturally occurring single nucleotide polymorphism (SNP) was recently found in the NAT gene in clinical isolates of M. tuberculosis. The nucle...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Kawamura, A, Sandy, J, Upton, A, Noble, M, Sim, E
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2003

Ижил төстэй зүйлс

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
-н: Fullam, E, зэрэг
Хэвлэсэн: (2009)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
-н: Brooke, E
Хэвлэсэн: (2003)

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.
-н: Sandy, J, зэрэг
Хэвлэсэн: (2002)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
-н: Abuhammad, A, зэрэг
Хэвлэсэн: (2010)

Structure and mechanism of arylamine N-acetyltransferases.
-н: Westwood, I, зэрэг
Хэвлэсэн: (2006)

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
-н: Sim, E, зэрэг
Хэвлэсэн: (2008)

Arylamine N-acetyltransferase in adult mouse brain
-н: Mo, M, зэрэг
Хэвлэсэн: (2004)

Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
-н: Abuhammad, A, зэрэг
Хэвлэсэн: (2010)

Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
-н: Wakefield, L, зэрэг
Хэвлэсэн: (2006)

Mapping the genes for arylamine N-acetyltransferases
-н: Fakis, G
Хэвлэсэн: (2000)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
-н: Anderton, M, зэрэг
Хэвлэсэн: (2006)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
-н: Laurieri, N, зэрэг
Хэвлэсэн: (2014)

Expression of the genes for arylamine N-acetyltransferases in mice
-н: Boukouvala, S, зэрэг
Хэвлэсэн: (2002)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
-н: Hiba Chelouti, зэрэг
Хэвлэсэн: (2017-08-01)

Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG
-н: Eltis, E
Хэвлэсэн: (2006)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
-н: Russell, A, зэрэг
Хэвлэсэн: (2009)

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
-н: Brooke, E, зэрэг
Хэвлэсэн: (2003)

Arylamine N-acetyltransferase expression during murine heart development
-н: Wakefield, L, зэрэг
Хэвлэсэн: (2004)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
-н: Amjad Mahasneh, зэрэг
Хэвлэсэн: (2012-01-01)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
-н: Westwood, I, зэрэг
Хэвлэсэн: (2011)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
-н: Wang, H, зэрэг
Хэвлэсэн: (2005)

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
-н: Kawamura, A, зэрэг
Хэвлэсэн: (2005)

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
-н: Westwood, I, зэрэг
Хэвлэсэн: (2010)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
-н: Xinning Liu, зэрэг
Хэвлэсэн: (2021-01-01)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
-н: Raúl A. Salazar-González, зэрэг
Хэвлэсэн: (2022-01-01)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
-н: Kawamura, A, зэрэг
Хэвлэсэн: (2004)

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.
-н: Abuhammad, A, зэрэг
Хэвлэсэн: (2013)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
-н: Madikane, V, зэрэг
Хэвлэсэн: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
-н: Madikane, V, зэрэг
Хэвлэсэн: (2007)

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
-н: Musbah O. M. Tanira, зэрэг
Хэвлэсэн: (2003-04-01)

Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
-н: Christelle Vangenot, зэрэг
Хэвлэсэн: (2019-07-01)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
-н: Mark A. Doll, зэрэг
Хэвлэсэн: (2017-07-01)

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
-н: Brooke, E, зэрэг
Хэвлэсэн: (2003)

Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy
-н: Abuhammad, A
Хэвлэсэн: (2013)

Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis.
-н: Fakis, G, зэрэг
Хэвлэсэн: (2007)

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
-н: Eneida Turiján-Espinoza, зэрэг
Хэвлэсэн: (2018-03-01)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
-н: Abuhammad, A, зэрэг
Хэвлэсэн: (2012)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
-н: Wakefield, L, зэрэг
Хэвлэсэн: (2008)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
-н: Laurieri, N, зэрэг
Хэвлэсэн: (2010)

Association of the cytochrome P450 and arylamine N-acetyltransferase gene polymorphisms with the incidence of head and neck cancer in Polish population
-н: Monika Gogolewska, зэрэг
Хэвлэсэн: (2023-12-01)