Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may prov...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797099803315798016 |
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| author | Anwar, M Cowley, A Moloney, M |
| author_facet | Anwar, M Cowley, A Moloney, M |
| author_sort | Anwar, M |
| collection | OXFORD |
| description | The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries. © 2010 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T05:28:47Z |
| format | Journal article |
| id | oxford-uuid:e17c2b5b-2044-43c5-be45-839b70521cc3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:47Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:e17c2b5b-2044-43c5-be45-839b70521cc32022-03-27T09:54:44ZNovel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e17c2b5b-2044-43c5-be45-839b70521cc3EnglishSymplectic Elements at Oxford2010Anwar, MCowley, AMoloney, MThe synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries. © 2010 Elsevier Ltd. All rights reserved. |
| spellingShingle | Anwar, M Cowley, A Moloney, M Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title_full | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title_fullStr | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title_full_unstemmed | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title_short | Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| title_sort | novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity |
| work_keys_str_mv | AT anwarm novelchiralpyrrolidinonescaffoldsderivedfromthreoninewithantibacterialactivity AT cowleya novelchiralpyrrolidinonescaffoldsderivedfromthreoninewithantibacterialactivity AT moloneym novelchiralpyrrolidinonescaffoldsderivedfromthreoninewithantibacterialactivity |