Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may prov...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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