Common variants at 11p13 are associated with susceptibility to tuberculosis.
After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1797099808355254272 |
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| author | Thye, T Owusu-Dabo, E Vannberg, F van Crevel, R Curtis, J Sahiratmadja, E Balabanova, Y Ehmen, C Muntau, B Ruge, G Sievertsen, J Gyapong, J Nikolayevskyy, V Hill, P Sirugo, G Drobniewski, F van de Vosse, E Newport, M Alisjahbana, B Nejentsev, S Ottenhoff, T Hill, A Horstmann, R Meyer, C |
| author_facet | Thye, T Owusu-Dabo, E Vannberg, F van Crevel, R Curtis, J Sahiratmadja, E Balabanova, Y Ehmen, C Muntau, B Ruge, G Sievertsen, J Gyapong, J Nikolayevskyy, V Hill, P Sirugo, G Drobniewski, F van de Vosse, E Newport, M Alisjahbana, B Nejentsev, S Ottenhoff, T Hill, A Horstmann, R Meyer, C |
| author_sort | Thye, T |
| collection | OXFORD |
| description | After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11). |
| first_indexed | 2024-03-07T05:28:52Z |
| format | Journal article |
| id | oxford-uuid:e182e08d-a9fd-44b3-a700-b8bcb6285145 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:28:52Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:e182e08d-a9fd-44b3-a700-b8bcb62851452022-03-27T09:54:59ZCommon variants at 11p13 are associated with susceptibility to tuberculosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e182e08d-a9fd-44b3-a700-b8bcb6285145EnglishSymplectic Elements at Oxford2012Thye, TOwusu-Dabo, EVannberg, Fvan Crevel, RCurtis, JSahiratmadja, EBalabanova, YEhmen, CMuntau, BRuge, GSievertsen, JGyapong, JNikolayevskyy, VHill, PSirugo, GDrobniewski, Fvan de Vosse, ENewport, MAlisjahbana, BNejentsev, SOttenhoff, THill, AHorstmann, RMeyer, CAfter imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11). |
| spellingShingle | Thye, T Owusu-Dabo, E Vannberg, F van Crevel, R Curtis, J Sahiratmadja, E Balabanova, Y Ehmen, C Muntau, B Ruge, G Sievertsen, J Gyapong, J Nikolayevskyy, V Hill, P Sirugo, G Drobniewski, F van de Vosse, E Newport, M Alisjahbana, B Nejentsev, S Ottenhoff, T Hill, A Horstmann, R Meyer, C Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title | Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title_full | Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title_fullStr | Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title_full_unstemmed | Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title_short | Common variants at 11p13 are associated with susceptibility to tuberculosis. |
| title_sort | common variants at 11p13 are associated with susceptibility to tuberculosis |
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