Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle insi...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2018
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| _version_ | 1797099823701164032 |
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| author | Bunnik, E Cook, K Varoquaux, N Batugedara, G Prudhomme, J Cort, A Shi, L Andolina, C Ross, L Brady, D Fidock, D Nosten, F Tewari, R Sinnis, P Ay, F Vert, J Noble, W Roch, L |
| author_facet | Bunnik, E Cook, K Varoquaux, N Batugedara, G Prudhomme, J Cort, A Shi, L Andolina, C Ross, L Brady, D Fidock, D Nosten, F Tewari, R Sinnis, P Ay, F Vert, J Noble, W Roch, L |
| author_sort | Bunnik, E |
| collection | OXFORD |
| description | The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle. |
| first_indexed | 2024-03-07T05:29:05Z |
| format | Journal article |
| id | oxford-uuid:e194fc49-4801-4e4a-8f6a-cfa15860a436 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:05Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:e194fc49-4801-4e4a-8f6a-cfa15860a4362022-03-27T09:55:34ZChanges in genome organization of parasite-specific gene families during the Plasmodium transmission stagesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e194fc49-4801-4e4a-8f6a-cfa15860a436EnglishSymplectic Elements at OxfordNature Publishing Group2018Bunnik, ECook, KVaroquaux, NBatugedara, GPrudhomme, JCort, AShi, LAndolina, CRoss, LBrady, DFidock, DNosten, FTewari, RSinnis, PAy, FVert, JNoble, WRoch, LThe development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells. Here, we analyze genome organization in the P. falciparum and P. vivax transmission stages. Major changes occur in the localization and interactions of genes involved in pathogenesis and immune evasion, host cell invasion, sexual differentiation, and master regulation of gene expression. Furthermore, we observe reorganization of subtelomeric heterochromatin around genes involved in host cell remodeling. Depletion of heterochromatin protein 1 (PfHP1) resulted in loss of interactions between virulence genes, confirming that PfHP1 is essential for maintenance of the repressive center. Our results suggest that the three-dimensional genome structure of human malaria parasites is strongly connected with transcriptional activity of specific gene families throughout the life cycle. |
| spellingShingle | Bunnik, E Cook, K Varoquaux, N Batugedara, G Prudhomme, J Cort, A Shi, L Andolina, C Ross, L Brady, D Fidock, D Nosten, F Tewari, R Sinnis, P Ay, F Vert, J Noble, W Roch, L Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title | Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title_full | Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title_fullStr | Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title_full_unstemmed | Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title_short | Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages |
| title_sort | changes in genome organization of parasite specific gene families during the plasmodium transmission stages |
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