Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life
<p><strong>Background</strong></p><p>Visceral adipose tissue (VAT) has been proposed to play a pathogenic role in Crohn’s disease (CD); however, prospective clinical data are lacking. The aim was to evaluate whether VAT, beyond body mass index (BMI), is associated with...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2018
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| _version_ | 1797099829653929984 |
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| author | Bryant, R Schultz, C Ooi, S Goess, C Costello, S Vincent, A Schoeman, S Lim, A Bartholomeusz, F Travis, S Andrews, J |
| author_facet | Bryant, R Schultz, C Ooi, S Goess, C Costello, S Vincent, A Schoeman, S Lim, A Bartholomeusz, F Travis, S Andrews, J |
| author_sort | Bryant, R |
| collection | OXFORD |
| description | <p><strong>Background</strong></p><p>Visceral adipose tissue (VAT) has been proposed to play a pathogenic role in Crohn’s disease (CD); however, prospective clinical data are lacking. The aim was to evaluate whether VAT, beyond body mass index (BMI), is associated with CD behavior, disease activity, quality of life (QoL), or outcomes.</p><p><strong>Methods</strong></p><p>Body composition data and clinical, anthropometric, disease activity (fecal calprotectin [FC]), and QoL scores were gathered prospectively on adults with CD at 0, 12, and 24 months. BMI and, VAT metrics (visceral adipose tissue volume [cm3]/height [m2] index and VAT:subcutaneous adipose tissue [SAT] ratio) were calculated. Inflammatory bowel disease–related surgery and hospitalization were recorded over extended follow-up (median, 51 months). Multivariable linear mixed effects and logistic regression analyses were performed.</p><p><strong>Results</strong></p><p>Ninety-seven participants were assessed at baseline (55% male; median age, 31 years), 84 at 12 months, and 72 at 24 months. VAT:SAT was positively associated with stricturing disease behavior (log odds ratio [OR], 1.7; 95% confidence interval [CI], 0.32 to 3; P = 0.01) and elevated FC in patients with ileocolonic disease (β, 1.3; 95% CI, 0.32 to 2.3; P = 0.01). VAT:SAT was associated with lower QoL, particularly in those with ileal disease (β, –12; 95% CI, –19 to –4.5; P = 0.05). However, no prospective associations were observed between serial VAT measurements and time to surgery or hospitalization. No correlations were found between BMI and disease behavior, activity, or QoL.</p><p><strong>Conclusion</strong></p><p>VAT:SAT, rather than BMI, is associated with stricturing CD behavior, elevated FC, and reduced QoL in a disease distribution–dependent manner. Further studies are required to substantiate the role of VAT as a useful biomarker in CD.</p> |
| first_indexed | 2024-03-07T05:29:11Z |
| format | Journal article |
| id | oxford-uuid:e19c6f89-40ee-4bc4-b023-fae2c0072c9d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:11Z |
| publishDate | 2018 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:e19c6f89-40ee-4bc4-b023-fae2c0072c9d2022-03-27T09:55:43ZVisceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of lifeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e19c6f89-40ee-4bc4-b023-fae2c0072c9dEnglishSymplectic Elements at OxfordOxford University Press2018Bryant, RSchultz, COoi, SGoess, CCostello, SVincent, ASchoeman, SLim, ABartholomeusz, FTravis, SAndrews, J<p><strong>Background</strong></p><p>Visceral adipose tissue (VAT) has been proposed to play a pathogenic role in Crohn’s disease (CD); however, prospective clinical data are lacking. The aim was to evaluate whether VAT, beyond body mass index (BMI), is associated with CD behavior, disease activity, quality of life (QoL), or outcomes.</p><p><strong>Methods</strong></p><p>Body composition data and clinical, anthropometric, disease activity (fecal calprotectin [FC]), and QoL scores were gathered prospectively on adults with CD at 0, 12, and 24 months. BMI and, VAT metrics (visceral adipose tissue volume [cm3]/height [m2] index and VAT:subcutaneous adipose tissue [SAT] ratio) were calculated. Inflammatory bowel disease–related surgery and hospitalization were recorded over extended follow-up (median, 51 months). Multivariable linear mixed effects and logistic regression analyses were performed.</p><p><strong>Results</strong></p><p>Ninety-seven participants were assessed at baseline (55% male; median age, 31 years), 84 at 12 months, and 72 at 24 months. VAT:SAT was positively associated with stricturing disease behavior (log odds ratio [OR], 1.7; 95% confidence interval [CI], 0.32 to 3; P = 0.01) and elevated FC in patients with ileocolonic disease (β, 1.3; 95% CI, 0.32 to 2.3; P = 0.01). VAT:SAT was associated with lower QoL, particularly in those with ileal disease (β, –12; 95% CI, –19 to –4.5; P = 0.05). However, no prospective associations were observed between serial VAT measurements and time to surgery or hospitalization. No correlations were found between BMI and disease behavior, activity, or QoL.</p><p><strong>Conclusion</strong></p><p>VAT:SAT, rather than BMI, is associated with stricturing CD behavior, elevated FC, and reduced QoL in a disease distribution–dependent manner. Further studies are required to substantiate the role of VAT as a useful biomarker in CD.</p> |
| spellingShingle | Bryant, R Schultz, C Ooi, S Goess, C Costello, S Vincent, A Schoeman, S Lim, A Bartholomeusz, F Travis, S Andrews, J Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title | Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title_full | Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title_fullStr | Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title_full_unstemmed | Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title_short | Visceral adipose tissue is associated with stricturing Crohn's disease Behavior, fecal calprotectin, and quality of life |
| title_sort | visceral adipose tissue is associated with stricturing crohn s disease behavior fecal calprotectin and quality of life |
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