Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids

Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids

This paper explores the computer modelling aided design and synthesis of β-N-acetylhexosaminidase inhibitors along with their applicability to human disease treatment through biological evaluation in both an enzymatic and cellular setting. We investigated the importance of individual stereocenters,...

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Bibliographic Details
Main Authors:	Glawar, A, Martínez, R, Ayers, B, Hollas, M, Ngo, N, Nakagawa, S, Kato, A, Butters, T, Fleet, G, Jenkinson, S
Format:	Journal article
Language:	English
Published:	Royal Society of Chemistry 2016

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