GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys.
Using an antibody to gamma-aminobutyric acid (GABA), we examined the optic nerves and optic tracts from macaque monkeys at the light and electron microscopic levels to determine if there is a possible inhibitory projection from the retina to the brain. All of the monkeys (n = 5) had GABA immunoposit...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1996
|
| _version_ | 1797099840856915968 |
|---|---|
| author | Wilson, JR Cowey, A Somogy, P |
| author_facet | Wilson, JR Cowey, A Somogy, P |
| author_sort | Wilson, JR |
| collection | OXFORD |
| description | Using an antibody to gamma-aminobutyric acid (GABA), we examined the optic nerves and optic tracts from macaque monkeys at the light and electron microscopic levels to determine if there is a possible inhibitory projection from the retina to the brain. All of the monkeys (n = 5) had GABA immunopositive axons that were evenly distributed in their optic nerves. These immunopositive axons were slightly larger than the axons around them and comprised an average of 2.6% of the axons in the nerves. Thus, their estimated total was about 44,000 axons per nerve. In the optic tracts, the GABA immunopositive axons were not distributed evenly, but were concentrated mostly in the ventromedial part, indicating that this retinal pathway probably goes to a midbrain destination such as the superior colliculus. The present findings provide further evidence that there is a GABAergic retinal projection to the brain in primates with currently unknown physiological influences. |
| first_indexed | 2024-03-07T05:29:21Z |
| format | Journal article |
| id | oxford-uuid:e1ad905b-6c96-4dd6-ab68-1fc66e2c35f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:21Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:e1ad905b-6c96-4dd6-ab68-1fc66e2c35f12022-03-27T09:56:04ZGABA immunopositive axons in the optic nerve and optic tract of macaque monkeys.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1ad905b-6c96-4dd6-ab68-1fc66e2c35f1EnglishSymplectic Elements at Oxford1996Wilson, JRCowey, ASomogy, PUsing an antibody to gamma-aminobutyric acid (GABA), we examined the optic nerves and optic tracts from macaque monkeys at the light and electron microscopic levels to determine if there is a possible inhibitory projection from the retina to the brain. All of the monkeys (n = 5) had GABA immunopositive axons that were evenly distributed in their optic nerves. These immunopositive axons were slightly larger than the axons around them and comprised an average of 2.6% of the axons in the nerves. Thus, their estimated total was about 44,000 axons per nerve. In the optic tracts, the GABA immunopositive axons were not distributed evenly, but were concentrated mostly in the ventromedial part, indicating that this retinal pathway probably goes to a midbrain destination such as the superior colliculus. The present findings provide further evidence that there is a GABAergic retinal projection to the brain in primates with currently unknown physiological influences. |
| spellingShingle | Wilson, JR Cowey, A Somogy, P GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title | GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title_full | GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title_fullStr | GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title_full_unstemmed | GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title_short | GABA immunopositive axons in the optic nerve and optic tract of macaque monkeys. |
| title_sort | gaba immunopositive axons in the optic nerve and optic tract of macaque monkeys |
| work_keys_str_mv | AT wilsonjr gabaimmunopositiveaxonsintheopticnerveandoptictractofmacaquemonkeys AT coweya gabaimmunopositiveaxonsintheopticnerveandoptictractofmacaquemonkeys AT somogyp gabaimmunopositiveaxonsintheopticnerveandoptictractofmacaquemonkeys |