Antidepressant drug action: a neuropsychological perspective.
Early effects of antidepressants on emotional processing can be seen in healthy volunteers and in depressed patients with a consistent pattern of effect in behavioral and neural (fMRI) outcome measures. This early positive-biasing of emotional processing could help explain why antidepressant drug tr...
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| Format: | Journal article |
| Language: | English |
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2010
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| Summary: | Early effects of antidepressants on emotional processing can be seen in healthy volunteers and in depressed patients with a consistent pattern of effect in behavioral and neural (fMRI) outcome measures. This early positive-biasing of emotional processing could help explain why antidepressant drug treatments have a delayed clinical onset of action, but suggest that the delay may occur because of the need for further psychological rather than neurophysiological processing. The identification of these early effects suggest that we need to look earlier on in the treatment cascade to begin to understand the complex effects of these drugs and that understanding both cognitive and pharmacological effects of treatments may be an important avenue for future study. |
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