The catechol-O-methyltransferase gene: its regulation and polymorphisms.
The catechol-O-methyltransferase (COMT) gene is of significant interest to neuroscience, due to its role in modulating dopamine function. COMT is dynamically regulated; its expression is altered during normal brain development and in response to environmental stimuli. In many cases the underlying mo...
| Tác giả chính: | |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2010
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| _version_ | 1826301256046477312 |
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| author | Tunbridge, E |
| author_facet | Tunbridge, E |
| author_sort | Tunbridge, E |
| collection | OXFORD |
| description | The catechol-O-methyltransferase (COMT) gene is of significant interest to neuroscience, due to its role in modulating dopamine function. COMT is dynamically regulated; its expression is altered during normal brain development and in response to environmental stimuli. In many cases the underlying molecular basis for these effects is unknown; however, in some cases (e.g., estrogenic regulation in the case of sex differences) regulatory mechanisms have been identified. COMT contains several functional polymorphisms and haplotypes, including the well-studied Val158Met polymorphism. Here I review the regulation of COMT and the functional polymorphisms within its sequence with respect to brain function. |
| first_indexed | 2024-03-07T05:29:38Z |
| format | Journal article |
| id | oxford-uuid:e1cc3650-db97-48d4-a986-c4e47273b611 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:38Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:e1cc3650-db97-48d4-a986-c4e47273b6112022-03-27T09:56:43ZThe catechol-O-methyltransferase gene: its regulation and polymorphisms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1cc3650-db97-48d4-a986-c4e47273b611EnglishSymplectic Elements at Oxford2010Tunbridge, EThe catechol-O-methyltransferase (COMT) gene is of significant interest to neuroscience, due to its role in modulating dopamine function. COMT is dynamically regulated; its expression is altered during normal brain development and in response to environmental stimuli. In many cases the underlying molecular basis for these effects is unknown; however, in some cases (e.g., estrogenic regulation in the case of sex differences) regulatory mechanisms have been identified. COMT contains several functional polymorphisms and haplotypes, including the well-studied Val158Met polymorphism. Here I review the regulation of COMT and the functional polymorphisms within its sequence with respect to brain function. |
| spellingShingle | Tunbridge, E The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title | The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title_full | The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title_fullStr | The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title_full_unstemmed | The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title_short | The catechol-O-methyltransferase gene: its regulation and polymorphisms. |
| title_sort | catechol o methyltransferase gene its regulation and polymorphisms |
| work_keys_str_mv | AT tunbridgee thecatecholomethyltransferasegeneitsregulationandpolymorphisms AT tunbridgee catecholomethyltransferasegeneitsregulationandpolymorphisms |