Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study.
BACKGROUND: Poor medication adherence is common among bipolar patients. METHOD: We examined prospective data from 2 cohorts of individuals from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study (1999-2005) with bipolar disorder. Clinical and sociodemographic features...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826301257041575936 |
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| author | Perlis, R Ostacher, M Miklowitz, D Hay, A Nierenberg, A Thase, M Sachs, G |
| author_facet | Perlis, R Ostacher, M Miklowitz, D Hay, A Nierenberg, A Thase, M Sachs, G |
| author_sort | Perlis, R |
| collection | OXFORD |
| description | BACKGROUND: Poor medication adherence is common among bipolar patients. METHOD: We examined prospective data from 2 cohorts of individuals from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study (1999-2005) with bipolar disorder. Clinical and sociodemographic features associated with missing at least 25% of doses of at least 1 medication were assessed using logistic regression, and a risk stratification model was developed and validated. RESULTS: Of 3,640 subjects with 48,287 follow-up visits, 871 (24%) reported nonadherence on 20% or more study visits. Clinical features significantly associated (P < .05) with poor adherence included rapid cycling, suicide attempts, earlier onset of illness, and current anxiety or alcohol use disorder. Nonadherence during the first 3 months of follow-up was associated with less improvement in functioning at 12-month follow-up (P < .03). A risk stratification model using clinical predictors accurately classified 80.6% of visits in an independent validation cohort. CONCLUSION: Risk for poor medication adherence can be estimated and may be useful in targeting interventions. |
| first_indexed | 2024-03-07T05:29:39Z |
| format | Journal article |
| id | oxford-uuid:e1cd81cd-6ac4-4a92-9ce2-c25dd648da27 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:39Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:e1cd81cd-6ac4-4a92-9ce2-c25dd648da272022-03-27T09:56:45ZClinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1cd81cd-6ac4-4a92-9ce2-c25dd648da27EnglishSymplectic Elements at Oxford2010Perlis, ROstacher, MMiklowitz, DHay, ANierenberg, AThase, MSachs, G BACKGROUND: Poor medication adherence is common among bipolar patients. METHOD: We examined prospective data from 2 cohorts of individuals from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study (1999-2005) with bipolar disorder. Clinical and sociodemographic features associated with missing at least 25% of doses of at least 1 medication were assessed using logistic regression, and a risk stratification model was developed and validated. RESULTS: Of 3,640 subjects with 48,287 follow-up visits, 871 (24%) reported nonadherence on 20% or more study visits. Clinical features significantly associated (P < .05) with poor adherence included rapid cycling, suicide attempts, earlier onset of illness, and current anxiety or alcohol use disorder. Nonadherence during the first 3 months of follow-up was associated with less improvement in functioning at 12-month follow-up (P < .03). A risk stratification model using clinical predictors accurately classified 80.6% of visits in an independent validation cohort. CONCLUSION: Risk for poor medication adherence can be estimated and may be useful in targeting interventions. |
| spellingShingle | Perlis, R Ostacher, M Miklowitz, D Hay, A Nierenberg, A Thase, M Sachs, G Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title | Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title_full | Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title_fullStr | Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title_full_unstemmed | Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title_short | Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. |
| title_sort | clinical features associated with poor pharmacologic adherence in bipolar disorder results from the step bd study |
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