Gold-coated plant virus as computed tomography imaging contrast agent
Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Beilstein-Institut
2019
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| _version_ | 1797099863757815808 |
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| author | Aljabali, AAA Zoubi, MS Al-Batanyeh, KM Al-Radaideh, A Obeid, MA Sharabi, A Alshaer, W Abufares, B Al-Zanati, T Tambuwala, MM Akbar, N Evans, DJ |
| author_facet | Aljabali, AAA Zoubi, MS Al-Batanyeh, KM Al-Radaideh, A Obeid, MA Sharabi, A Alshaer, W Abufares, B Al-Zanati, T Tambuwala, MM Akbar, N Evans, DJ |
| author_sort | Aljabali, AAA |
| collection | OXFORD |
| description | Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types. |
| first_indexed | 2024-03-07T05:29:41Z |
| format | Journal article |
| id | oxford-uuid:e1cf85ce-3bf8-45ea-bc04-5e1ec3415d93 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:29:41Z |
| publishDate | 2019 |
| publisher | Beilstein-Institut |
| record_format | dspace |
| spelling | oxford-uuid:e1cf85ce-3bf8-45ea-bc04-5e1ec3415d932022-03-27T09:56:51ZGold-coated plant virus as computed tomography imaging contrast agentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1cf85ce-3bf8-45ea-bc04-5e1ec3415d93EnglishSymplectic Elements at OxfordBeilstein-Institut2019Aljabali, AAAZoubi, MSAl-Batanyeh, KMAl-Radaideh, AObeid, MASharabi, AAlshaer, WAbufares, BAl-Zanati, TTambuwala, MMAkbar, NEvans, DJChemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types. |
| spellingShingle | Aljabali, AAA Zoubi, MS Al-Batanyeh, KM Al-Radaideh, A Obeid, MA Sharabi, A Alshaer, W Abufares, B Al-Zanati, T Tambuwala, MM Akbar, N Evans, DJ Gold-coated plant virus as computed tomography imaging contrast agent |
| title | Gold-coated plant virus as computed tomography imaging contrast agent |
| title_full | Gold-coated plant virus as computed tomography imaging contrast agent |
| title_fullStr | Gold-coated plant virus as computed tomography imaging contrast agent |
| title_full_unstemmed | Gold-coated plant virus as computed tomography imaging contrast agent |
| title_short | Gold-coated plant virus as computed tomography imaging contrast agent |
| title_sort | gold coated plant virus as computed tomography imaging contrast agent |
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