| 要約: | <p>This thesis describes the preparation and study of acyclic, macrocyclic and mechanicallyinterlocked host molecules (MIMs) exploiting halogen and chalcogen bonding interactions for anion recognition and sensing.</p> <p><b>Chapter 1</b> introduces the field of anion supramolecular chemistry and interlocked structures, with emphasis on halogen and chalcogen bonding receptors, as well as their applications in catalysis, molecular recognition and nanotechnology.</p> <p><b>Chapter 2</b> explores the methodology development and synthesis of novel neutral and cationic macrocyclic and interlocked host molecules containing stable triazole-based halogen and chalcogen bonding motifs. The thermodynamic anion binding properties of these novel host molecules in wet and dry organic solvents are determined and compared.</p> <p><b>Chapter 3</b> details the applications and influences of halogen and chalcogen bonding interactions for electrochemical anion sensing. The ability of ferrocene-based halogen bonding receptors to enhance the sensitivity of redox anion sensing compared with hydrogen bonding host analogues is demonstrated.</p> <p><b>Chapter 4</b> investigates the unprecedented applications of halogen and chalcogen bonding interactions in enantioselective binding and sensing of chiral anions. The use of chiral [2]- and [3]rotaxanes for chiral anion discrimination is also demonstrated for the first time.</p> <p><b>Chapter 5</b> describes the exploitation of hydrophilic polyether-based cationic halogen bonding receptors for anion binding and sensing in water. In particular, the halogen bondingmediated recognition of oxoanions such as perrhenate and biologically-relevant phosphate species are discussed.</p> <p><b>Chapter 6</b> summarises the main conclusions of this thesis.</p> <p><b>Chapter 7</b> details the experimental procedures employed in this work, including synthetic protocols and characterisation data for novel compounds.</p> <p>Additional information pertaining to crystallographic data, electrochemical measurements and computational modelling procedures are provided in the Appendices.</p>
|
|---|