Halogen and chalcogen bonding host molecules for anion recognition and sensing
<p>This thesis describes the preparation and study of acyclic, macrocyclic and mechanicallyinterlocked host molecules (MIMs) exploiting halogen and chalcogen bonding interactions for anion recognition and sensing.</p> <p><b>Chapter 1</b> introduces the field of anion su...
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| Format: | Thesis |
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2017
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| _version_ | 1826301278429380608 |
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| author | Lim, J |
| author2 | Beer, P |
| author_facet | Beer, P Lim, J |
| author_sort | Lim, J |
| collection | OXFORD |
| description | <p>This thesis describes the preparation and study of acyclic, macrocyclic and mechanicallyinterlocked host molecules (MIMs) exploiting halogen and chalcogen bonding interactions for anion recognition and sensing.</p> <p><b>Chapter 1</b> introduces the field of anion supramolecular chemistry and interlocked structures, with emphasis on halogen and chalcogen bonding receptors, as well as their applications in catalysis, molecular recognition and nanotechnology.</p> <p><b>Chapter 2</b> explores the methodology development and synthesis of novel neutral and cationic macrocyclic and interlocked host molecules containing stable triazole-based halogen and chalcogen bonding motifs. The thermodynamic anion binding properties of these novel host molecules in wet and dry organic solvents are determined and compared.</p> <p><b>Chapter 3</b> details the applications and influences of halogen and chalcogen bonding interactions for electrochemical anion sensing. The ability of ferrocene-based halogen bonding receptors to enhance the sensitivity of redox anion sensing compared with hydrogen bonding host analogues is demonstrated.</p> <p><b>Chapter 4</b> investigates the unprecedented applications of halogen and chalcogen bonding interactions in enantioselective binding and sensing of chiral anions. The use of chiral [2]- and [3]rotaxanes for chiral anion discrimination is also demonstrated for the first time.</p> <p><b>Chapter 5</b> describes the exploitation of hydrophilic polyether-based cationic halogen bonding receptors for anion binding and sensing in water. In particular, the halogen bondingmediated recognition of oxoanions such as perrhenate and biologically-relevant phosphate species are discussed.</p> <p><b>Chapter 6</b> summarises the main conclusions of this thesis.</p> <p><b>Chapter 7</b> details the experimental procedures employed in this work, including synthetic protocols and characterisation data for novel compounds.</p> <p>Additional information pertaining to crystallographic data, electrochemical measurements and computational modelling procedures are provided in the Appendices.</p> |
| first_indexed | 2024-03-07T05:29:59Z |
| format | Thesis |
| id | oxford-uuid:e1eb91e7-d635-40a9-aea5-6bbf9bedb56b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T05:29:59Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | oxford-uuid:e1eb91e7-d635-40a9-aea5-6bbf9bedb56b2022-03-27T09:57:31ZHalogen and chalcogen bonding host molecules for anion recognition and sensingThesishttp://purl.org/coar/resource_type/c_db06uuid:e1eb91e7-d635-40a9-aea5-6bbf9bedb56bORA Deposit2017Lim, JBeer, P<p>This thesis describes the preparation and study of acyclic, macrocyclic and mechanicallyinterlocked host molecules (MIMs) exploiting halogen and chalcogen bonding interactions for anion recognition and sensing.</p> <p><b>Chapter 1</b> introduces the field of anion supramolecular chemistry and interlocked structures, with emphasis on halogen and chalcogen bonding receptors, as well as their applications in catalysis, molecular recognition and nanotechnology.</p> <p><b>Chapter 2</b> explores the methodology development and synthesis of novel neutral and cationic macrocyclic and interlocked host molecules containing stable triazole-based halogen and chalcogen bonding motifs. The thermodynamic anion binding properties of these novel host molecules in wet and dry organic solvents are determined and compared.</p> <p><b>Chapter 3</b> details the applications and influences of halogen and chalcogen bonding interactions for electrochemical anion sensing. The ability of ferrocene-based halogen bonding receptors to enhance the sensitivity of redox anion sensing compared with hydrogen bonding host analogues is demonstrated.</p> <p><b>Chapter 4</b> investigates the unprecedented applications of halogen and chalcogen bonding interactions in enantioselective binding and sensing of chiral anions. The use of chiral [2]- and [3]rotaxanes for chiral anion discrimination is also demonstrated for the first time.</p> <p><b>Chapter 5</b> describes the exploitation of hydrophilic polyether-based cationic halogen bonding receptors for anion binding and sensing in water. In particular, the halogen bondingmediated recognition of oxoanions such as perrhenate and biologically-relevant phosphate species are discussed.</p> <p><b>Chapter 6</b> summarises the main conclusions of this thesis.</p> <p><b>Chapter 7</b> details the experimental procedures employed in this work, including synthetic protocols and characterisation data for novel compounds.</p> <p>Additional information pertaining to crystallographic data, electrochemical measurements and computational modelling procedures are provided in the Appendices.</p> |
| spellingShingle | Lim, J Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title | Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title_full | Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title_fullStr | Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title_full_unstemmed | Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title_short | Halogen and chalcogen bonding host molecules for anion recognition and sensing |
| title_sort | halogen and chalcogen bonding host molecules for anion recognition and sensing |
| work_keys_str_mv | AT limj halogenandchalcogenbondinghostmoleculesforanionrecognitionandsensing |