Conformational change and selectivity in explicitly hydrated carbohydrates
The combination of vibrational spectroscopy, conducted in a supersonic jet expansion, with computation through molecular mechanics, density functional theory (DFT) and ab initio calculation, has provided a new approach to the conformational and structural assignment of carbohydrates and their molecu...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797099905353777152 |
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| author | Simons, J Davis, B Cocinero, E Gamblin, D Stanca-Kaposta, E |
| author_facet | Simons, J Davis, B Cocinero, E Gamblin, D Stanca-Kaposta, E |
| author_sort | Simons, J |
| collection | OXFORD |
| description | The combination of vibrational spectroscopy, conducted in a supersonic jet expansion, with computation through molecular mechanics, density functional theory (DFT) and ab initio calculation, has provided a new approach to the conformational and structural assignment of carbohydrates and their molecular complexes. This article reviews the new insights it has provided on the regioselectivity and conformational choice in singly and multiply hydrated monosaccharides. It reveals a systematic pattern of conformational preference and binding site selectivity, driven by the provision of optimal, co-operative hydrogen-bonded networks in the hydrated sugars. Water binding is invariably 'focused' around the hydroxymethyl group (when present); the bound water molecules (on multiply hydrated mannose) are located exclusively on its hydrophilic face while the hydrophobic face remains 'dry'; and there is a correlation between the locale of the preferred binding sites and those involved in protein-carbohydrate molecular recognition. © 2009 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-07T05:30:10Z |
| format | Journal article |
| id | oxford-uuid:e1fb5f23-684f-4384-935f-b2485bf05d8a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:30:10Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:e1fb5f23-684f-4384-935f-b2485bf05d8a2022-03-27T09:57:57ZConformational change and selectivity in explicitly hydrated carbohydratesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1fb5f23-684f-4384-935f-b2485bf05d8aEnglishSymplectic Elements at Oxford2009Simons, JDavis, BCocinero, EGamblin, DStanca-Kaposta, EThe combination of vibrational spectroscopy, conducted in a supersonic jet expansion, with computation through molecular mechanics, density functional theory (DFT) and ab initio calculation, has provided a new approach to the conformational and structural assignment of carbohydrates and their molecular complexes. This article reviews the new insights it has provided on the regioselectivity and conformational choice in singly and multiply hydrated monosaccharides. It reveals a systematic pattern of conformational preference and binding site selectivity, driven by the provision of optimal, co-operative hydrogen-bonded networks in the hydrated sugars. Water binding is invariably 'focused' around the hydroxymethyl group (when present); the bound water molecules (on multiply hydrated mannose) are located exclusively on its hydrophilic face while the hydrophobic face remains 'dry'; and there is a correlation between the locale of the preferred binding sites and those involved in protein-carbohydrate molecular recognition. © 2009 Elsevier Ltd. All rights reserved. |
| spellingShingle | Simons, J Davis, B Cocinero, E Gamblin, D Stanca-Kaposta, E Conformational change and selectivity in explicitly hydrated carbohydrates |
| title | Conformational change and selectivity in explicitly hydrated carbohydrates |
| title_full | Conformational change and selectivity in explicitly hydrated carbohydrates |
| title_fullStr | Conformational change and selectivity in explicitly hydrated carbohydrates |
| title_full_unstemmed | Conformational change and selectivity in explicitly hydrated carbohydrates |
| title_short | Conformational change and selectivity in explicitly hydrated carbohydrates |
| title_sort | conformational change and selectivity in explicitly hydrated carbohydrates |
| work_keys_str_mv | AT simonsj conformationalchangeandselectivityinexplicitlyhydratedcarbohydrates AT davisb conformationalchangeandselectivityinexplicitlyhydratedcarbohydrates AT cocineroe conformationalchangeandselectivityinexplicitlyhydratedcarbohydrates AT gamblind conformationalchangeandselectivityinexplicitlyhydratedcarbohydrates AT stancakapostae conformationalchangeandselectivityinexplicitlyhydratedcarbohydrates |