Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria.
Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this study, the effect of IL-10 on their production by peripheral blood mononuclear cells (PBMC) from acutely infected patients was examined. Exoge...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
1998
|
| _version_ | 1826301294829109248 |
|---|---|
| author | Ho, M Schollaardt, T Snape, S Looareesuwan, S Suntharasamai, P White, N |
| author_facet | Ho, M Schollaardt, T Snape, S Looareesuwan, S Suntharasamai, P White, N |
| author_sort | Ho, M |
| collection | OXFORD |
| description | Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this study, the effect of IL-10 on their production by peripheral blood mononuclear cells (PBMC) from acutely infected patients was examined. Exogenous IL-10 inhibited malarial antigen-induced cytokine production by reducing mRNA accumulation. Maximal inhibition occurred when IL-10 was added in the first 2 h of stimulation. Conversely, the addition of anti-IL-10 markedly enhanced TNF-alpha, IL-1beta, and IL-6 production. The effect was significantly greater on PBMC from patients with uncomplicated infection than PBMC from patients with severe disease. Kinetics studies showed that TNF-alpha, IL-6, and IL-1beta were produced within 2-4 h of stimulation, while IL-10 was first detectable after 8 h. These findings suggest that IL-10 counter-regulates the proinflammatory response to P. falciparum. Severe falciparum malaria may be associated with an inadequate negative feedback response by IL-10. |
| first_indexed | 2024-03-07T05:30:13Z |
| format | Journal article |
| id | oxford-uuid:e1ff9582-5ea3-4606-ba85-8c70a17123b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:30:13Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:e1ff9582-5ea3-4606-ba85-8c70a17123b02022-03-27T09:58:08ZEndogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e1ff9582-5ea3-4606-ba85-8c70a17123b0EnglishSymplectic Elements at Oxford1998Ho, MSchollaardt, TSnape, SLooareesuwan, SSuntharasamai, PWhite, NTumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this study, the effect of IL-10 on their production by peripheral blood mononuclear cells (PBMC) from acutely infected patients was examined. Exogenous IL-10 inhibited malarial antigen-induced cytokine production by reducing mRNA accumulation. Maximal inhibition occurred when IL-10 was added in the first 2 h of stimulation. Conversely, the addition of anti-IL-10 markedly enhanced TNF-alpha, IL-1beta, and IL-6 production. The effect was significantly greater on PBMC from patients with uncomplicated infection than PBMC from patients with severe disease. Kinetics studies showed that TNF-alpha, IL-6, and IL-1beta were produced within 2-4 h of stimulation, while IL-10 was first detectable after 8 h. These findings suggest that IL-10 counter-regulates the proinflammatory response to P. falciparum. Severe falciparum malaria may be associated with an inadequate negative feedback response by IL-10. |
| spellingShingle | Ho, M Schollaardt, T Snape, S Looareesuwan, S Suntharasamai, P White, N Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title | Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title_full | Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title_fullStr | Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title_full_unstemmed | Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title_short | Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. |
| title_sort | endogenous interleukin 10 modulates proinflammatory response in plasmodium falciparum malaria |
| work_keys_str_mv | AT hom endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria AT schollaardtt endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria AT snapes endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria AT looareesuwans endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria AT suntharasamaip endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria AT whiten endogenousinterleukin10modulatesproinflammatoryresponseinplasmodiumfalciparummalaria |