Impaired TLR5 functionality is associated with survival in melioidosis.

Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR5(1174C)>T, to elucidate the role of TLR5 in melioidosis. W...

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Bibliografiska uppgifter
Huvudupphovsmän: West, T, Chantratita, N, Chierakul, W, Limmathurotsakul, D, Wuthiekanun, V, Myers, N, Emond, M, Wurfel, M, Hawn, T, Peacock, S, Skerrett, S
Materialtyp: Journal article
Språk:English
Publicerad: 2013