Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3(-/-) mice and analyzed the neuronal phenotype. Reduced apoptosis in superior cerv...

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Bibliographic Details
Main Authors: Bishop, T, Gallagher, D, Pascual, A, Lygate, C, de Bono, J, Nicholls, L, Ortega-Saenz, P, Oster, H, Wijeyekoon, B, Sutherland, A, Grosfeld, A, Aragones, J, Schneider, M, van Geyte, K, Teixeira, D, Diez-Juan, A, Lopez-Barneo, J, Channon, K, Maxwell, P, Pugh, C, Davies, A, Carmeliet, P, Ratcliffe, P
Format: Journal article
Language:English
Published: 2008

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