OS-9: another piece in the HIF complex story.
In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involve...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| Summary: | In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005). |
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