The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern
There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here report that PF- 332 exerts equipotent in vitro act...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1797109416015691776 |
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| author | Abdelnabi, R Foo, CS Jochmans, D Vangeel, L De Jonghe, S Augustijns, P Mols, R Weynand, B Wattanakul, T Hoglund, RM Tarning, J Mowbray, CE Sjö, P Escudié, F Scandale, I Chatelain, E Neyts, J |
| author_facet | Abdelnabi, R Foo, CS Jochmans, D Vangeel, L De Jonghe, S Augustijns, P Mols, R Weynand, B Wattanakul, T Hoglund, RM Tarning, J Mowbray, CE Sjö, P Escudié, F Scandale, I Chatelain, E Neyts, J |
| author_sort | Abdelnabi, R |
| collection | OXFORD |
| description | There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here report that PF- 332 exerts equipotent in vitro activity against the four SARS-CoV-2 variants of concerns (VoC) and that it can completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface. Treatment of Syrian Golden hamsters with PF-332 (250 mg/kg, twice daily) completely protected the animals against intranasal infection with the beta (B.1.351) and delta (B.1.617.2) SARS-CoV-2 variants. Moreover, treatment of SARS-CoV-2 (B.1.617.2) infected animals with PF-332 completely prevented transmission to untreated co-housed sentinels. |
| first_indexed | 2024-03-07T07:41:37Z |
| format | Journal article |
| id | oxford-uuid:e281aa95-0529-46c9-b24e-c3e666b93be3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:41:37Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:e281aa95-0529-46c9-b24e-c3e666b93be32023-04-21T09:29:20ZThe oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concernJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e281aa95-0529-46c9-b24e-c3e666b93be3EnglishSymplectic ElementsSpringer Nature2022Abdelnabi, RFoo, CSJochmans, DVangeel, LDe Jonghe, SAugustijns, PMols, RWeynand, BWattanakul, THoglund, RMTarning, JMowbray, CESjö, PEscudié, FScandale, IChatelain, ENeyts, JThere is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here report that PF- 332 exerts equipotent in vitro activity against the four SARS-CoV-2 variants of concerns (VoC) and that it can completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface. Treatment of Syrian Golden hamsters with PF-332 (250 mg/kg, twice daily) completely protected the animals against intranasal infection with the beta (B.1.351) and delta (B.1.617.2) SARS-CoV-2 variants. Moreover, treatment of SARS-CoV-2 (B.1.617.2) infected animals with PF-332 completely prevented transmission to untreated co-housed sentinels. |
| spellingShingle | Abdelnabi, R Foo, CS Jochmans, D Vangeel, L De Jonghe, S Augustijns, P Mols, R Weynand, B Wattanakul, T Hoglund, RM Tarning, J Mowbray, CE Sjö, P Escudié, F Scandale, I Chatelain, E Neyts, J The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title | The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title_full | The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title_fullStr | The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title_full_unstemmed | The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title_short | The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV- 2 variants of concern |
| title_sort | oral protease inhibitor pf 07321332 protects syrian hamsters against infection with sars cov 2 variants of concern |
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