Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
The non-heme ferrous dependent oxidase isopenicillin N synthase (IPNS) catalyses the biosynthesis of isopenicillin N from a tripeptide substrate. The crystal structure of Aspergillus nidulans IPNS complexed to manganese reveals a six co-ordinate metal ligated by two water molecules and four protein...
Главные авторы: | Sami, M, Brown, T, Roach, P, Schofield, C, Baldwin, J |
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Формат: | Journal article |
Язык: | English |
Опубликовано: |
1997
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