Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.

Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.

Show other versions (1)

OBJECTIVE: Nicotinic acid (NA) treatment has been associated with benefits in atherosclerosis that are usually attributed to effects on plasma lipoproteins. The NA receptor GPR109A is expressed in monocytes and macrophages, suggesting a possible additional role for NA in modulating function of these...

Full description

Bibliographic Details
Main Authors:	Digby, J, Martinez, F, Jefferson, A, Ruparelia, N, Chai, J, Wamil, M, Greaves, D, Choudhury, R
Format:	Journal article
Language:	English
Published:	2012

Similar Items

Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms
by: Digby, J, et al.
Published: (2012)

Anti-inflammatory Effects of Nicotinic Acid: Mechanisms of Action in Human Monocytes
by: Digby, J, et al.
Published: (2011)

NICOTINIC ACID RECEPTOR GPR109A IS DOWN-REGULATED IN HUMAN MACROPHAGE-DERIVED FOAM CELLS
by: Chai, J, et al.
Published: (2013)

Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells
by: Chai, J, et al.
Published: (2013)

Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells.
by: Joshua T Chai, et al.
Published: (2013-01-01)

GPR109A and vascular inflammation.
by: Chai, J, et al.
Published: (2013)

GPR109A and Vascular Inflammation
by: Chai, J, et al.
Published: (2013)

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin.
by: Digby, J, et al.
Published: (2010)

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
by: Digby, J, et al.
Published: (2010)

Anti-inflammatory Effects of Nicotinic Acid: Suppression of Fractalkine, RANTES, and MCP-1 and Upregulation of Adiponectin in 3T3-L1 Adipocytes
by: Digby, J, et al.
Published: (2008)

Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism
by: Fabio Takeo Sato, et al.
Published: (2020-09-01)

Upregulation of GPR109A in Parkinson's disease.
by: Chandramohan Wakade, et al.
Published: (2014-01-01)

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
by: Jin-Ran Chen, et al.
Published: (2021-01-01)

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G)
by: Ning Ren, et al.
Published: (2009-05-01)

EXOGENOUS MICROPARTICLES OF IRON OXIDE BIND TO ACTIVATED ENDOTHELIAL CELLS BUT, UNLIKE MONOCYTES, DO NOT TRIGGER AN ENDOTHELIAL RESPONSE
by: Jefferson, A, et al.
Published: (2013)

Exogenous microparticles of iron oxide bind to activated endothelial cells but, unlike monocytes, do not trigger an endothelial response.
by: Jefferson, A, et al.
Published: (2013)

Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
by: Kiran Kumar Adepu, et al.
Published: (2021-11-01)

Nicotinic acid and the prevention of coronary artery disease.
by: Digby, J, et al.
Published: (2009)

Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx
by: Shu‐jie Zhang, et al.
Published: (2021-05-01)

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
by: Kyle Taing, et al.
Published: (2023-01-01)

GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
by: Taeyeop Park, et al.
Published: (2019-11-01)

Niacin in cardiovascular disease: Recent preclinical and clinical developments
by: Digby, J, et al.
Published: (2012)

Niacin in cardiovascular disease: recent preclinical and clinical developments.
by: Digby, J, et al.
Published: (2012)

Effects of niacin on atherosclerosis and vascular function.
by: Ruparelia, N, et al.
Published: (2011)

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
by: Yonggan Sun, et al.
Published: (2023-11-01)

Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice
by: Daiki Masukawa, et al.
Published: (2020-10-01)

Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A
by: Changyu Kang, et al.
Published: (2022-12-01)

Monocytes in acute myocardial infarction
by: Ruparelia, N
Published: (2013)

Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84
by: Luscombe, VB, et al.
Published: (2023)

Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects
by: Wenji Zhang, et al.
Published: (2022-02-01)

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages
by: Kenneth R. Feingold, et al.
Published: (2014-12-01)

Harnessing Monocytes for a Liposomal Rosiglitazone-Mediated Anti-Inflammatory Effect
by: Osnat Shvindelman, et al.
Published: (2022-09-01)

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival.
by: Stéphanie St-Pierre, et al.
Published: (2016-01-01)

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus.
by: Ruparelia, N, et al.
Published: (2013)

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus
by: Ruparelia, N, et al.
Published: (2013)

MYOCARDIAL INFARCTION CAUSES INFLAMMATION AND LEUKOCYTE RECRUITMENT AT REMOTE SITES IN THE MYOCARDIUM AND IN THE RENAL GLOMERULUS
by: Ruparelia, N, et al.
Published: (2013)

The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A
by: Egils Bisenieks, et al.
Published: (2021-09-01)

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway
by: Yanglin Wu, et al.
Published: (2021-06-01)

The anti-inflammatory stage of monocytes after long-term stimulation with LPS is mediated by p38 MAP kinase dependent epigenetic silencing
by: Viemann D, et al.
Published: (2008-09-01)

Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients
by: Zahra Abedi Kichi, et al.
Published: (2022-07-01)