A short biomimetic synthesis of the meroterpenoids guajadial and psidial A.

The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psidial A in an aqueous three-component coupling reac...

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Bibliographic Details
Main Authors: Lawrence, A, Adlington, R, Baldwin, J, Lee, V, Kershaw, J, Thompson, A
Format: Journal article
Language:English
Published: 2010
Description
Summary:The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psidial A in an aqueous three-component coupling reaction, between caryophyllene, benzaldehyde, and diformylphloroglucinol.