Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation
The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after tr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2018
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| _version_ | 1797100059535343616 |
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| author | Cunningham, P Maidstone, R Durrington, H Venkateswaran, R Cypel, M Keshavjee, S Gibbs, J Loudon, A Chow, C Ray, D Blaikley, J |
| author_facet | Cunningham, P Maidstone, R Durrington, H Venkateswaran, R Cypel, M Keshavjee, S Gibbs, J Loudon, A Chow, C Ray, D Blaikley, J |
| author_sort | Cunningham, P |
| collection | OXFORD |
| description | The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBα directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands. |
| first_indexed | 2024-03-07T05:32:24Z |
| format | Journal article |
| id | oxford-uuid:e2b5b258-1aeb-47d5-b6d1-995783f83f47 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:32:24Z |
| publishDate | 2018 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:e2b5b258-1aeb-47d5-b6d1-995783f83f472022-03-27T10:03:31ZIncidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e2b5b258-1aeb-47d5-b6d1-995783f83f47EnglishSymplectic Elements at OxfordBMJ Publishing Group2018Cunningham, PMaidstone, RDurrington, HVenkateswaran, RCypel, MKeshavjee, SGibbs, JLoudon, AChow, CRay, DBlaikley, JThe importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBα directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands. |
| spellingShingle | Cunningham, P Maidstone, R Durrington, H Venkateswaran, R Cypel, M Keshavjee, S Gibbs, J Loudon, A Chow, C Ray, D Blaikley, J Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title | Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title_full | Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title_fullStr | Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title_full_unstemmed | Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title_short | Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
| title_sort | incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation |
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