Synthesis and glycosidase inhibition of the enantiomer of (-)-steviamine, the first example of a new class of indolizidine alkaloid.

(+)-Steviamine, the enantiomer of the natural (-)-steviamine, and its corresponding C5 epimer have been synthesized from the D-ribose-derived cyclic nitrone. (-)-Steviamine was found to be the first naturally occurring iminosugar that causes any inhibition of alpha-galactosaminidases.

書目詳細資料
Main Authors: Hu, X, Bartholomew, B, Nash, R, Wilson, F, Fleet, G, Nakagawa, S, Kato, A, Jia, Y, van Well, R, Yu, C
格式: Journal article
語言:English
出版: 2010