Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients

Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients

Introduction Regulatory T cell (Treg) therapy has been demonstrated to facilitate long-term allograft survival in preclinical models of transplantation and may permit reduction of immunosuppression and its associated complications in the clinical setting. Phase 1 clinical trials have shown Treg ther...

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Main Authors: Brook, MO, Hester, J, Petchey, W, Rombach, I, Dutton, S, Bottomley, MJ, Black, J, Abdul-Wahab, S, Bushell, A, Lombardi, G, Wood, K, Friend, P, Harden, P, Issa, F
פורמט: Journal article
שפה:English
יצא לאור: BMJ Publishing Group 2022

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