OCT angiography-based detection and quantification of the neovascular network in exudative AMD
Purpose: To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD. Methods: Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neov...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Association for Research in Vision and Ophthalmology
2016
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| _version_ | 1797100175003484160 |
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| author | Lindner, M Fang, P Steinberg, J Domdei, N Pfau, M Krohne, T Schmitz-Valckenberg, S Holz, F Fleckenstein, M |
| author_facet | Lindner, M Fang, P Steinberg, J Domdei, N Pfau, M Krohne, T Schmitz-Valckenberg, S Holz, F Fleckenstein, M |
| author_sort | Lindner, M |
| collection | OXFORD |
| description | Purpose: To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD. Methods: Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neovascular network was measured by three independent readers. Interclass-correlation coefficient and area overlap coefficients (OC) were calculated to assess locally precise agreement between measurements. As a reference for interreader agreement, the extent of the neovascular network was further measured on fluorescein angiography (FA) images. Results: A total of 31 eyes (27 patients, mean age 82.5 years, 15 female) were included in the study. Neovascularization subtype was classified as type I in 5, type II in 11, type III in 9, and mixed in 6 eyes, respectively. Interreader agreement for measurements of the neovascular network was 0.884 for OCT-A and 0.636 for FA. Overlap coefficient was 0.705 (interquartile [IQR]: 0.450-0.76) for OCT-A and 0.704 (IQR: 0.673-0.750) for FA, respectively. Area agreement was weaker in type III and mixed lesions. Conclusions: Optical coherence tomography angiography-based measurements of the new vessel complex in neovascular AMD are feasible with interreader agreement comparable with the values obtained for FA. The results underscore the potential of OCT-A as a noninvasive diagnostic tool in neovascular AMD. Yet, further studies will be required to reveal the origin of poor agreement observed in single eyes and to advance OCT-A toward dependable use (e.g., in a reading center context). |
| first_indexed | 2024-03-07T05:34:00Z |
| format | Journal article |
| id | oxford-uuid:e33bca69-a3a8-4622-8a7b-5b7411125a91 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:34:00Z |
| publishDate | 2016 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | oxford-uuid:e33bca69-a3a8-4622-8a7b-5b7411125a912022-03-27T10:07:42ZOCT angiography-based detection and quantification of the neovascular network in exudative AMDJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e33bca69-a3a8-4622-8a7b-5b7411125a91EnglishSymplectic Elements at OxfordAssociation for Research in Vision and Ophthalmology2016Lindner, MFang, PSteinberg, JDomdei, NPfau, MKrohne, TSchmitz-Valckenberg, SHolz, FFleckenstein, MPurpose: To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD. Methods: Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neovascular network was measured by three independent readers. Interclass-correlation coefficient and area overlap coefficients (OC) were calculated to assess locally precise agreement between measurements. As a reference for interreader agreement, the extent of the neovascular network was further measured on fluorescein angiography (FA) images. Results: A total of 31 eyes (27 patients, mean age 82.5 years, 15 female) were included in the study. Neovascularization subtype was classified as type I in 5, type II in 11, type III in 9, and mixed in 6 eyes, respectively. Interreader agreement for measurements of the neovascular network was 0.884 for OCT-A and 0.636 for FA. Overlap coefficient was 0.705 (interquartile [IQR]: 0.450-0.76) for OCT-A and 0.704 (IQR: 0.673-0.750) for FA, respectively. Area agreement was weaker in type III and mixed lesions. Conclusions: Optical coherence tomography angiography-based measurements of the new vessel complex in neovascular AMD are feasible with interreader agreement comparable with the values obtained for FA. The results underscore the potential of OCT-A as a noninvasive diagnostic tool in neovascular AMD. Yet, further studies will be required to reveal the origin of poor agreement observed in single eyes and to advance OCT-A toward dependable use (e.g., in a reading center context). |
| spellingShingle | Lindner, M Fang, P Steinberg, J Domdei, N Pfau, M Krohne, T Schmitz-Valckenberg, S Holz, F Fleckenstein, M OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title | OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title_full | OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title_fullStr | OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title_full_unstemmed | OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title_short | OCT angiography-based detection and quantification of the neovascular network in exudative AMD |
| title_sort | oct angiography based detection and quantification of the neovascular network in exudative amd |
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