Description and nomenclature of Neisseria meningitidis capsule locus
<p>Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular p...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2013
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| _version_ | 1826301557167095808 |
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| author | Harrison, O Claus, H Jiang, Y Bennett, J Bratcher, H Jolley, K Corton, C Care, R Poolman, J Zollinger, W Frasch, C Stephens, D Feavers, I Frosch, M Parkhill, J Vogel, U Quail, M Bentley, S Maiden, M |
| author_facet | Harrison, O Claus, H Jiang, Y Bennett, J Bratcher, H Jolley, K Corton, C Care, R Poolman, J Zollinger, W Frasch, C Stephens, D Feavers, I Frosch, M Parkhill, J Vogel, U Quail, M Bentley, S Maiden, M |
| author_sort | Harrison, O |
| collection | OXFORD |
| description | <p>Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.</p> |
| first_indexed | 2024-03-07T05:34:12Z |
| format | Journal article |
| id | oxford-uuid:e351d144-2819-4f2b-b8d6-53bad32cded1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:34:12Z |
| publishDate | 2013 |
| publisher | Centers for Disease Control and Prevention |
| record_format | dspace |
| spelling | oxford-uuid:e351d144-2819-4f2b-b8d6-53bad32cded12022-03-27T10:08:20ZDescription and nomenclature of Neisseria meningitidis capsule locusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e351d144-2819-4f2b-b8d6-53bad32cded1EnglishSymplectic Elements at OxfordCenters for Disease Control and Prevention2013Harrison, OClaus, HJiang, YBennett, JBratcher, HJolley, KCorton, CCare, RPoolman, JZollinger, WFrasch, CStephens, DFeavers, IFrosch, MParkhill, JVogel, UQuail, MBentley, SMaiden, M <p>Pathogenic Neisseria meningitidis isolates contain a polysaccharide capsule that is the main virulence determinant for this bacterium. Thirteen capsular polysaccharides have been described, and nuclear magnetic resonance spectroscopy has enabled determination of the structure of capsular polysaccharides responsible for serogroup specificity. Molecular mechanisms involved in N. meningitidis capsule biosynthesis have also been identified, and genes involved in this process and in cell surface translocation are clustered at a single chromosomal locus termed cps. The use of multiple names for some of the genes involved in capsule synthesis, combined with the need for rapid diagnosis of serogroups commonly associated with invasive meningococcal disease, prompted a requirement for a consistent approach to the nomenclature of capsule genes. In this report, a comprehensive description of all N. meningitidis serogroups is provided, along with a proposed nomenclature, which was presented at the 2012 XVIIIth International Pathogenic Neisseria Conference.</p> |
| spellingShingle | Harrison, O Claus, H Jiang, Y Bennett, J Bratcher, H Jolley, K Corton, C Care, R Poolman, J Zollinger, W Frasch, C Stephens, D Feavers, I Frosch, M Parkhill, J Vogel, U Quail, M Bentley, S Maiden, M Description and nomenclature of Neisseria meningitidis capsule locus |
| title | Description and nomenclature of Neisseria meningitidis capsule locus |
| title_full | Description and nomenclature of Neisseria meningitidis capsule locus |
| title_fullStr | Description and nomenclature of Neisseria meningitidis capsule locus |
| title_full_unstemmed | Description and nomenclature of Neisseria meningitidis capsule locus |
| title_short | Description and nomenclature of Neisseria meningitidis capsule locus |
| title_sort | description and nomenclature of neisseria meningitidis capsule locus |
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