Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797100207422308352 |
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| author | Fan, X Medved, M Foxley, S River, J Zamora, M Karczmar, G Corot, C Robert, P Bourrinet, P |
| author_facet | Fan, X Medved, M Foxley, S River, J Zamora, M Karczmar, G Corot, C Robert, P Bourrinet, P |
| author_sort | Fan, X |
| collection | OXFORD |
| description | An intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats. Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors. |
| first_indexed | 2024-03-07T05:34:29Z |
| format | Journal article |
| id | oxford-uuid:e36a64f0-3779-49af-837e-55eaa61f834b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:34:29Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:e36a64f0-3779-49af-837e-55eaa61f834b2022-03-27T10:08:59ZMulti-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e36a64f0-3779-49af-837e-55eaa61f834bEnglishSymplectic Elements at Oxford2006Fan, XMedved, MFoxley, SRiver, JZamora, MKarczmar, GCorot, CRobert, PBourrinet, PAn intermediate molecular weight contrast agent P760 was used to investigate the ability of multi-slice dynamic contrast-enhanced MRI (DCE-MRI) to distinguish metastatic from non-metastatic rodent prostate tumors. Non-metastatic AT2.1 and metastatic AT3.1 prostate tumors originally derived from the Dunning prostate cancer model were implanted on the hind leg of Copenhagen rats. Multi-sliced DCE-MRI data were acquired on a SIGNA 1.5 T scanner and analyzed using a recently developed empirical mathematical model. The P760 multi-slice DCE-MRI data in combination with the empirical mathematical model successfully distinguished between metastatic and non-metastatic rodent prostate tumors. Specifically, fitting the data with the empirical model showed that metastatic tumors had significantly faster contrast media uptake (p<0.001) and slower washout rates (p<0.01) than non-metastatic tumors. |
| spellingShingle | Fan, X Medved, M Foxley, S River, J Zamora, M Karczmar, G Corot, C Robert, P Bourrinet, P Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title | Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title_full | Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title_fullStr | Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title_full_unstemmed | Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title_short | Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors. |
| title_sort | multi slice dce mri data using p760 distinguishes between metastatic and non metastatic rodent prostate tumors |
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