Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases.
AIM: To analyse the expression of heat shock protein (HSP) 60 in biliary epithelium in auto-immune liver conditions and also in chronic cholestatic and other liver diseases. METHODS: Hepatic expression of HSP-60 in frozen liver biopsy specimens from patients with primary sclerosing cholangitis (PSC)...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1826301579282612224 |
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| author | Martins, E Chapman, R Marron, K Fleming, K |
| author_facet | Martins, E Chapman, R Marron, K Fleming, K |
| author_sort | Martins, E |
| collection | OXFORD |
| description | AIM: To analyse the expression of heat shock protein (HSP) 60 in biliary epithelium in auto-immune liver conditions and also in chronic cholestatic and other liver diseases. METHODS: Hepatic expression of HSP-60 in frozen liver biopsy specimens from patients with primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), auto-immune hepatitis (AIH), obstructive jaundice (LDO), alcoholic liver disease (ALD), and from normal controls was studied by immunohistochemistry using the APAAP technique and confocal laser scanning microscopy. RESULTS: Increased expression of HSP-60 was demonstrated in the biliary epithelium of patients with PBC, LDO and, to a lesser extent, with PSC. Focal, weaker, biliary epithelial expression of HSP-60 was observed in AIH, ALD and normal liver tissue. Increased expression was also seen on Kupffer cells in LDO and in hepatocytes in areas of piecemeal necrosis in AIH. CONCLUSION: Enhanced biliary expression of HSP-60 is a common feature of chronic biliary disease irrespective of aetiology and is not specific to auto-immune diseases. |
| first_indexed | 2024-03-07T05:34:32Z |
| format | Journal article |
| id | oxford-uuid:e36eb982-b9a1-4199-b3ef-9bb89337578c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:34:32Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:e36eb982-b9a1-4199-b3ef-9bb89337578c2022-03-27T10:09:05ZBiliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e36eb982-b9a1-4199-b3ef-9bb89337578cEnglishSymplectic Elements at Oxford1996Martins, EChapman, RMarron, KFleming, KAIM: To analyse the expression of heat shock protein (HSP) 60 in biliary epithelium in auto-immune liver conditions and also in chronic cholestatic and other liver diseases. METHODS: Hepatic expression of HSP-60 in frozen liver biopsy specimens from patients with primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), auto-immune hepatitis (AIH), obstructive jaundice (LDO), alcoholic liver disease (ALD), and from normal controls was studied by immunohistochemistry using the APAAP technique and confocal laser scanning microscopy. RESULTS: Increased expression of HSP-60 was demonstrated in the biliary epithelium of patients with PBC, LDO and, to a lesser extent, with PSC. Focal, weaker, biliary epithelial expression of HSP-60 was observed in AIH, ALD and normal liver tissue. Increased expression was also seen on Kupffer cells in LDO and in hepatocytes in areas of piecemeal necrosis in AIH. CONCLUSION: Enhanced biliary expression of HSP-60 is a common feature of chronic biliary disease irrespective of aetiology and is not specific to auto-immune diseases. |
| spellingShingle | Martins, E Chapman, R Marron, K Fleming, K Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title | Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title_full | Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title_fullStr | Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title_full_unstemmed | Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title_short | Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases. |
| title_sort | biliary expression of heat shock protein a non specific feature of chronic cholestatic liver diseases |
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